Natural products: A lead for drug discovery and development

Natural products are used since ancient times in folklore for the treatment of various ailments. Plant‐derived products have been recognized for many years as a source of therapeutic agents and structural diversity. A literature survey has been carried out to determine the utility of natural molecul...

Full description

Saved in:
Bibliographic Details
Published in:Phytotherapy research 2021-09, Vol.35 (9), p.4660-4702
Main Authors: Chopra, Bhawna, Dhingra, Ashwani Kumar
Format: Article
Language:English
Subjects:
bioactivity
Chemical compounds
Drug development
Drug discovery
Literature reviews
modifications
Natural products
Pharmacology
therapeutic agents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Natural products are used since ancient times in folklore for the treatment of various ailments. Plant‐derived products have been recognized for many years as a source of therapeutic agents and structural diversity. A literature survey has been carried out to determine the utility of natural molecules and their modified analogs or derivatives as pharmacological active entities. This review presents a study on the importance of natural products in terms of drug discovery and development. It describes how the natural components can be utilized after small modifications in new perspectives. Various new modifications in structure offer a unique opportunity to establish a new molecular entity with better pharmacological potential. It was concluded that in this current era, new attempts are taken to utilize the compounds derived from natural sources as novel drug candidates, with a focus to find and discover new effective molecules that were referred to as “new entities of natural product drug discovery.”
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.7099