Elevated chemokines concentration is associated with disease activity in Takayasu arteritis

• Published in: Cytokine (Philadelphia, Pa.) Pa.), 2021-07, Vol.143, p.155515-155515, Article 155515
• Main Authors: Dong, Hui, Zhang, Yan, Zou, Yubao, Chen, Yang, Yue, Jingxia, Liu, Haiying, Jiang, Xiongjing
• Format: Article
• Language: English
• Subjects: Adult; Blood Sedimentation; Case-Control Studies; Chemokines; Chemokines - blood; Disease activity; Female; Humans; Inflammation - blood; Male; ROC Curve; Sensitivity and Specificity; Takayasu arteritis; Takayasu Arteritis - blood; Takayasu Arteritis - diagnosis; Takayasu Arteritis - pathology
• ISSN: 1043-4666; 1096-0023
• DOI: 10.1016/j.cyto.2021.155515

•The levels of CCL2, 3, 20, and CXCL8, 10 are increased in takayasu arteritis.•The levels of CCL2, 20 and CXCL8, 10 are elevated in active takayasu arteritis.•High-sensitivity of CCL2, 20, and CXCL8, 10, despite classic biomarkers negative. Chemokines were seldom investigated in Takayasu arteritis (TA) patients. This study aimed to evaluate the plasma levels of chemokines and their association with disease activity, including C-C chemokine ligand (CCL) 2, CCL3, CCL11, CCL20, C-X-C chemokine ligand (CXCL) 8 and CXCL10. Chemokines were measured in 85 TA patients, and 28 age- and gender-matched healthy controls. The disease activity of these TA patients was assessed according to the National Institute of Health (NIH) criteria. The relationship between the plasma levels of chemokines and disease activity was analyzed. Among the 85 TA patients, 24 (28.2%) patients had active disease according to the NIH criteria. Significantly increased levels of CCL2, CCL3, CCL20, CXCL8 and CXCL10 were observed in TA patients when compared to healthy controls, while increased levels of CCL2, CCL20, CXCL8 and CXCL10 in TA patients with active disease when compared to those with inactive disease (all p