Elevated chemokines concentration is associated with disease activity in Takayasu arteritis

•The levels of CCL2, 3, 20, and CXCL8, 10 are increased in takayasu arteritis.•The levels of CCL2, 20 and CXCL8, 10 are elevated in active takayasu arteritis.•High-sensitivity of CCL2, 20, and CXCL8, 10, despite classic biomarkers negative. Chemokines were seldom investigated in Takayasu arteritis (...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2021-07, Vol.143, p.155515-155515, Article 155515
Main Authors: Dong, Hui, Zhang, Yan, Zou, Yubao, Chen, Yang, Yue, Jingxia, Liu, Haiying, Jiang, Xiongjing
Format: Article
Language:English
Subjects:
Adult
Blood Sedimentation
Case-Control Studies
Chemokines
Chemokines - blood
Disease activity
Female
Humans
Inflammation - blood
Male
ROC Curve
Sensitivity and Specificity
Takayasu arteritis
Takayasu Arteritis - blood
Takayasu Arteritis - diagnosis
Takayasu Arteritis - pathology
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cited_by cdi_FETCH-LOGICAL-c356t-e1d5f18097234d500e74f1231f6a2b46df0660f893e431e33c280d968603ae9c3
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container_title Cytokine (Philadelphia, Pa.)
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creator Dong, Hui
Zhang, Yan
Zou, Yubao
Chen, Yang
Yue, Jingxia
Liu, Haiying
Jiang, Xiongjing
description •The levels of CCL2, 3, 20, and CXCL8, 10 are increased in takayasu arteritis.•The levels of CCL2, 20 and CXCL8, 10 are elevated in active takayasu arteritis.•High-sensitivity of CCL2, 20, and CXCL8, 10, despite classic biomarkers negative. Chemokines were seldom investigated in Takayasu arteritis (TA) patients. This study aimed to evaluate the plasma levels of chemokines and their association with disease activity, including C-C chemokine ligand (CCL) 2, CCL3, CCL11, CCL20, C-X-C chemokine ligand (CXCL) 8 and CXCL10. Chemokines were measured in 85 TA patients, and 28 age- and gender-matched healthy controls. The disease activity of these TA patients was assessed according to the National Institute of Health (NIH) criteria. The relationship between the plasma levels of chemokines and disease activity was analyzed. Among the 85 TA patients, 24 (28.2%) patients had active disease according to the NIH criteria. Significantly increased levels of CCL2, CCL3, CCL20, CXCL8 and CXCL10 were observed in TA patients when compared to healthy controls, while increased levels of CCL2, CCL20, CXCL8 and CXCL10 in TA patients with active disease when compared to those with inactive disease (all p 
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Chemokines were seldom investigated in Takayasu arteritis (TA) patients. This study aimed to evaluate the plasma levels of chemokines and their association with disease activity, including C-C chemokine ligand (CCL) 2, CCL3, CCL11, CCL20, C-X-C chemokine ligand (CXCL) 8 and CXCL10. Chemokines were measured in 85 TA patients, and 28 age- and gender-matched healthy controls. The disease activity of these TA patients was assessed according to the National Institute of Health (NIH) criteria. The relationship between the plasma levels of chemokines and disease activity was analyzed. Among the 85 TA patients, 24 (28.2%) patients had active disease according to the NIH criteria. Significantly increased levels of CCL2, CCL3, CCL20, CXCL8 and CXCL10 were observed in TA patients when compared to healthy controls, while increased levels of CCL2, CCL20, CXCL8 and CXCL10 in TA patients with active disease when compared to those with inactive disease (all p &lt; 0.05). The plasma cut-off values of CCL2, CCL20, CXCL8 and CXCL10 were 309.6 pg/ml, 131.4 pg/ml, 4.7 pg/ml, and 282.1 pg/ml, which maximized the ability of disease activity assessment and had a sensitivity/specificity of 66.7%/67.2%, 54.2%/77.1%,70.8%/72.1%,83.3%/54.1%, respectively (p &lt; 0.05). Among patients with negative erythrocyte sedimentation rate, C-reactive protein or high-sensitivity C-reactive protein, CCL2, CCL20, CXCL8, and CXCL10 still had a high-sensitivity to recognize patients in the active phase. 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Chemokines were seldom investigated in Takayasu arteritis (TA) patients. This study aimed to evaluate the plasma levels of chemokines and their association with disease activity, including C-C chemokine ligand (CCL) 2, CCL3, CCL11, CCL20, C-X-C chemokine ligand (CXCL) 8 and CXCL10. Chemokines were measured in 85 TA patients, and 28 age- and gender-matched healthy controls. The disease activity of these TA patients was assessed according to the National Institute of Health (NIH) criteria. The relationship between the plasma levels of chemokines and disease activity was analyzed. Among the 85 TA patients, 24 (28.2%) patients had active disease according to the NIH criteria. Significantly increased levels of CCL2, CCL3, CCL20, CXCL8 and CXCL10 were observed in TA patients when compared to healthy controls, while increased levels of CCL2, CCL20, CXCL8 and CXCL10 in TA patients with active disease when compared to those with inactive disease (all p &lt; 0.05). 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Chemokines were seldom investigated in Takayasu arteritis (TA) patients. This study aimed to evaluate the plasma levels of chemokines and their association with disease activity, including C-C chemokine ligand (CCL) 2, CCL3, CCL11, CCL20, C-X-C chemokine ligand (CXCL) 8 and CXCL10. Chemokines were measured in 85 TA patients, and 28 age- and gender-matched healthy controls. The disease activity of these TA patients was assessed according to the National Institute of Health (NIH) criteria. The relationship between the plasma levels of chemokines and disease activity was analyzed. Among the 85 TA patients, 24 (28.2%) patients had active disease according to the NIH criteria. Significantly increased levels of CCL2, CCL3, CCL20, CXCL8 and CXCL10 were observed in TA patients when compared to healthy controls, while increased levels of CCL2, CCL20, CXCL8 and CXCL10 in TA patients with active disease when compared to those with inactive disease (all p &lt; 0.05). The plasma cut-off values of CCL2, CCL20, CXCL8 and CXCL10 were 309.6 pg/ml, 131.4 pg/ml, 4.7 pg/ml, and 282.1 pg/ml, which maximized the ability of disease activity assessment and had a sensitivity/specificity of 66.7%/67.2%, 54.2%/77.1%,70.8%/72.1%,83.3%/54.1%, respectively (p &lt; 0.05). Among patients with negative erythrocyte sedimentation rate, C-reactive protein or high-sensitivity C-reactive protein, CCL2, CCL20, CXCL8, and CXCL10 still had a high-sensitivity to recognize patients in the active phase. This study showed that the expression level of CCL2, CCL20, CXCL8 and CXCL10 was elevated in active TA patients, indicating that these chemokines might act as potential biomarkers in evaluating the disease activity.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33849766</pmid><doi>10.1016/j.cyto.2021.155515</doi><tpages>1</tpages></addata></record>
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subjects Adult
Blood Sedimentation
Case-Control Studies
Chemokines
Chemokines - blood
Disease activity
Female
Humans
Inflammation - blood
Male
ROC Curve
Sensitivity and Specificity
Takayasu arteritis
Takayasu Arteritis - blood
Takayasu Arteritis - diagnosis
Takayasu Arteritis - pathology
title Elevated chemokines concentration is associated with disease activity in Takayasu arteritis
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