Can Biomarkers Guide Oncolytic Virus Immunotherapy?

Defects in tumor cell IFNγ signaling is associated with resistance to immune checkpoint inhibitors. Recently, these defects were found to confer increased sensitivity to oncolytic virus infection. Differential expression of innate sensing elements in tumor cells may serve as predictive biomarkers of...

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Bibliographic Details
Published in:Clinical cancer research 2021-06, Vol.27 (12), p.3278-3279
Main Author: Kaufman, Howard L
Format: Article
Language:English
Subjects:
Biomarkers
Humans
Immunologic Factors
Immunotherapy
Neoplasms - therapy
Oncolytic Virotherapy
Oncolytic Viruses - genetics
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Description
Summary:Defects in tumor cell IFNγ signaling is associated with resistance to immune checkpoint inhibitors. Recently, these defects were found to confer increased sensitivity to oncolytic virus infection. Differential expression of innate sensing elements in tumor cells may serve as predictive biomarkers of oncolytic virus immunotherapy in patients with cancer. .
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-21-0660