Non-invasive fibrosis assessments of non-alcoholic fatty liver disease associated with low estimated glomerular filtration rate among CKD patients: the Fukuoka Kidney disease Registry Study

• Published in: Clinical and experimental nephrology 2021-08, Vol.25 (8), p.822-834
• Main Authors: Hara, Masatoshi, Tanaka, Shigeru, Torisu, Kumiko, Matsukuma, Yuta, Tsuchimoto, Akihiro, Tokumoto, Masanori, Ooboshi, Hiroaki, Nakano, Toshiaki, Tsuruya, Kazuhiko, Kitazono, Takanari
• Format: Article
• Language: English
• Subjects: Aged; Albuminuria - blood; Albuminuria - pathology; Biopsy; Creatinine; Cross-Sectional Studies; Epidermal growth factor receptors; Fatty liver; Female; Fibrosis; Glomerular Filtration Rate; Humans; Kidney - pathology; Kidney diseases; Liver diseases; Male; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; Non-alcoholic Fatty Liver Disease - physiopathology; Original Article; Registries; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - pathology; Renal Insufficiency, Chronic - physiopathology; Risk factors; Severity of Illness Index; Urology
• ISSN: 1342-1751; 1437-7799
• DOI: 10.1007/s10157-020-02018-z

Background A growing body of evidence has shown that non-alcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD). Non-invasive fibrosis assessments of NAFLD such as Fibrosis-4 (FIB-4) index and NAFLD fibrosis score (NFS) have been developed to substitute liver biopsy. Little is known about the association between FIB-4 index or NFS and the components of CKD. Methods In the present cross-sectional study, we assessed of 3640 Japanese CKD patients. We examined the association between FIB-4index or NFS and the odds of having low estimated glomerular filtration rate (eGFR) defined as eGFR