Astrocytes have a license to kill inflammatory T cells

Microbiome-induced interferon signaling through gut-derived natural killer cells is integral to minimize peripheral inflammatory responses in the brain and spinal cord. In a recent issue of Nature, Sanmarco, Wheeler, et al. define how interferon signaling induces LAMP1+TRAIL+ astrocytes, which cause...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2021-04, Vol.54 (4), p.614-616
Main Authors: Kwon, Alice H.K., Liddelow, Shane A.
Format: Article
Language:English
Subjects:
Apoptosis
Astrocytes
Brain
Cell death
CRISPR
Cytokines
Degeneration
Disease
Inflammation
Interferon
Ligands
Lymphocytes
Lymphocytes T
Microbiomes
Natural killer cells
Neurodegeneration
Pathogenesis
Physiology
Signaling
Spinal cord
Tumor necrosis factor-TNF
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Summary:Microbiome-induced interferon signaling through gut-derived natural killer cells is integral to minimize peripheral inflammatory responses in the brain and spinal cord. In a recent issue of Nature, Sanmarco, Wheeler, et al. define how interferon signaling induces LAMP1+TRAIL+ astrocytes, which cause death of inflammatory T cells, mitigating degeneration in a mouse model of demyealination. Microbiome-induced interferon signaling through gut-derived natural killer cells is integral to minimize peripheral inflammatory responses in the brain and spinal cord. In a recent issue of Nature, Sanmarco, Wheeler, et al. define how interferon signaling induces LAMP1+TRAIL+ astrocytes, which cause death of inflammatory T cells, mitigating degeneration in a mouse model of demyealination.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2021.03.015