Clinical Efficacy of Ruxolitinib Monotherapy and Haploidentical Hematopoeitic Stem Cell Transplantation in a Child with Philadelphia Chromosome-like Relapsed/Refractory acute lymphoblastic leukemia

INTRODUCTION(Ph-like) ALL is a subset of leukemia which has a gene expression profile similar to Ph+disease, but without the presence of BCR-ABL1 translocation. CASE DESCRIPTIONWe reported an exceptional case of a child with relapsed Ph-like ALL with IKZF1 gene deletion treated with high-dose ruxoli...

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Bibliographic Details
Published in:Pediatric transplantation 2021, Vol.25 (4), p.e14024-e14024
Main Authors: Bayram, Nihan, Yaman, Yöntem, Özdilli, Kürşat, Telhan, Leyla, Nepesov, Serdar, Bilgen, Hülya, Elli, Murat, Behar, Sude Sema, Anak, Sema
Format: Report
Language:English
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Summary:INTRODUCTION(Ph-like) ALL is a subset of leukemia which has a gene expression profile similar to Ph+disease, but without the presence of BCR-ABL1 translocation. CASE DESCRIPTIONWe reported an exceptional case of a child with relapsed Ph-like ALL with IKZF1 gene deletion treated with high-dose ruxolitinib as monotherapy, after multi-agent chemotherapy. He remains in continued MRD-negative leukemia remission with full donor chimerism at 12 months post-HSCT. DISCUSSIONThe circumstance that makes our case featured is the usage of ruxolitinib as monotherapy. This report, we believe, is a pioneering report for a frequent disease with a high risk of failure for the outcome.
ISSN:1399-3046
DOI:10.1111/petr.14024