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Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children With Cerebral Palsy
Objective To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin-like growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age- and gender-matched controls. Methods A cross-sectional study enrolled 30 children in each group: CP w...
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| Published in: | Indian pediatrics 2021-09, Vol.58 (9), p.836-838 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c344t-cb80977a5af3f78170ae14814420108f8bd65e7eb67ef07c41ee12c190aac9083 |
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| cites | cdi_FETCH-LOGICAL-c344t-cb80977a5af3f78170ae14814420108f8bd65e7eb67ef07c41ee12c190aac9083 |
| container_end_page | 838 |
| container_issue | 9 |
| container_start_page | 836 |
| container_title | Indian pediatrics |
| container_volume | 58 |
| creator | Gwasikoti, Namita Bhalla, Kapil Kaushik, Jaya Shankar Ghalaut, Veena Singh Kundu, Zile Singh |
| description | Objective
To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin-like growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age- and gender-matched controls.
Methods
A cross-sectional study enrolled 30 children in each group: CP with epilepsy, CP without epilepsy, and healthy controls. Bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.
Results
z-scores of BMD [−1.80 (1.03), −2.12 (0.85) vs −1.40 (0.90);
P |
| doi_str_mv | 10.1007/s13312-021-2303-6 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2514607265</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2514607265</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-cb80977a5af3f78170ae14814420108f8bd65e7eb67ef07c41ee12c190aac9083</originalsourceid><addsrcrecordid>eNp9kE9P3DAQxa2qVaGUD8Cl8rEH3M7Yjp0cYflTpIVWagtHy0kmJShxwE4q7bevV0s5cpqR5r2neT_GjhC-IID9mlAplAIkCqlACfOG7UNltbBFUb3NO2AlDBjcYx9SegCQShb4nu0pVRqtC9xn7W0_-7EP_OyYn06B-HUfKPqBn1FI_bzhPrT8J8Vl5FeXFwL5mv7SwLPhZgrCj_Uy-HmKG76674c2UuB3_XzPVxSp3sb88EPafGTvujzp8HkesN8X579W38T6--XV6mQtGqX1LJq6zN9bX_hOdbZEC55Ql6i1BISyK-vWFGSpNpY6sI1GIpQNVuB9U0GpDtjnXe5jnJ4WSrMb-9TQMPhA05JcLq8NWGmKLMWdtIlTSpE69xj70ceNQ3BbuG4H12W4bgvXmez59By_1CO1L47_NLNA7gQpn8Ifiu5hWmLIlV9J_QczhoKM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2514607265</pqid></control><display><type>article</type><title>Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children With Cerebral Palsy</title><source>Springer Nature</source><source>Alma/SFX Local Collection</source><creator>Gwasikoti, Namita ; Bhalla, Kapil ; Kaushik, Jaya Shankar ; Ghalaut, Veena Singh ; Kundu, Zile Singh</creator><creatorcontrib>Gwasikoti, Namita ; Bhalla, Kapil ; Kaushik, Jaya Shankar ; Ghalaut, Veena Singh ; Kundu, Zile Singh</creatorcontrib><description>Objective
To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin-like growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age- and gender-matched controls.
Methods
A cross-sectional study enrolled 30 children in each group: CP with epilepsy, CP without epilepsy, and healthy controls. Bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.
Results
z-scores of BMD [−1.80 (1.03), −2.12 (0.85) vs −1.40 (0.90);
P
<0.01], 25-OHD levels [19.26 (8.28), 20.59 (8.92) Vs 26.79 (12.76) ng/mL;
P
<0.01] and IGF-1 levels [20.90 (6.42), 23.37 (8.11) vs 31.77 (11.21) ng/mL;
P
<0.01] were significantly low among children with CP with epilepsy, CP without epilepsy when compared to controls.
Conclusion
Children with CP with or without comorbid epilepsy were prone to vitamin D deficiency, low bone mineral density and growth hormone axis suppression with low IGF-1 levels.</description><identifier>ISSN: 0019-6061</identifier><identifier>EISSN: 0974-7559</identifier><identifier>DOI: 10.1007/s13312-021-2303-6</identifier><identifier>PMID: 33864451</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Bone Density ; Cerebral Palsy - epidemiology ; Child ; Cross-Sectional Studies ; Humans ; Insulin-Like Growth Factor I ; Maternal and Child Health ; Medicine ; Medicine & Public Health ; Pediatric Surgery ; Pediatrics ; Research Paper ; Vitamin D</subject><ispartof>Indian pediatrics, 2021-09, Vol.58 (9), p.836-838</ispartof><rights>Indian Academy of Pediatrics 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-cb80977a5af3f78170ae14814420108f8bd65e7eb67ef07c41ee12c190aac9083</citedby><cites>FETCH-LOGICAL-c344t-cb80977a5af3f78170ae14814420108f8bd65e7eb67ef07c41ee12c190aac9083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33864451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gwasikoti, Namita</creatorcontrib><creatorcontrib>Bhalla, Kapil</creatorcontrib><creatorcontrib>Kaushik, Jaya Shankar</creatorcontrib><creatorcontrib>Ghalaut, Veena Singh</creatorcontrib><creatorcontrib>Kundu, Zile Singh</creatorcontrib><title>Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children With Cerebral Palsy</title><title>Indian pediatrics</title><addtitle>Indian Pediatr</addtitle><addtitle>Indian Pediatr</addtitle><description>Objective
To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin-like growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age- and gender-matched controls.
Methods
A cross-sectional study enrolled 30 children in each group: CP with epilepsy, CP without epilepsy, and healthy controls. Bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.
Results
z-scores of BMD [−1.80 (1.03), −2.12 (0.85) vs −1.40 (0.90);
P
<0.01], 25-OHD levels [19.26 (8.28), 20.59 (8.92) Vs 26.79 (12.76) ng/mL;
P
<0.01] and IGF-1 levels [20.90 (6.42), 23.37 (8.11) vs 31.77 (11.21) ng/mL;
P
<0.01] were significantly low among children with CP with epilepsy, CP without epilepsy when compared to controls.
Conclusion
Children with CP with or without comorbid epilepsy were prone to vitamin D deficiency, low bone mineral density and growth hormone axis suppression with low IGF-1 levels.</description><subject>Bone Density</subject><subject>Cerebral Palsy - epidemiology</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I</subject><subject>Maternal and Child Health</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Research Paper</subject><subject>Vitamin D</subject><issn>0019-6061</issn><issn>0974-7559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE9P3DAQxa2qVaGUD8Cl8rEH3M7Yjp0cYflTpIVWagtHy0kmJShxwE4q7bevV0s5cpqR5r2neT_GjhC-IID9mlAplAIkCqlACfOG7UNltbBFUb3NO2AlDBjcYx9SegCQShb4nu0pVRqtC9xn7W0_-7EP_OyYn06B-HUfKPqBn1FI_bzhPrT8J8Vl5FeXFwL5mv7SwLPhZgrCj_Uy-HmKG76674c2UuB3_XzPVxSp3sb88EPafGTvujzp8HkesN8X579W38T6--XV6mQtGqX1LJq6zN9bX_hOdbZEC55Ql6i1BISyK-vWFGSpNpY6sI1GIpQNVuB9U0GpDtjnXe5jnJ4WSrMb-9TQMPhA05JcLq8NWGmKLMWdtIlTSpE69xj70ceNQ3BbuG4H12W4bgvXmez59By_1CO1L47_NLNA7gQpn8Ifiu5hWmLIlV9J_QczhoKM</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Gwasikoti, Namita</creator><creator>Bhalla, Kapil</creator><creator>Kaushik, Jaya Shankar</creator><creator>Ghalaut, Veena Singh</creator><creator>Kundu, Zile Singh</creator><general>Springer India</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210901</creationdate><title>Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children With Cerebral Palsy</title><author>Gwasikoti, Namita ; Bhalla, Kapil ; Kaushik, Jaya Shankar ; Ghalaut, Veena Singh ; Kundu, Zile Singh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-cb80977a5af3f78170ae14814420108f8bd65e7eb67ef07c41ee12c190aac9083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bone Density</topic><topic>Cerebral Palsy - epidemiology</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I</topic><topic>Maternal and Child Health</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Research Paper</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gwasikoti, Namita</creatorcontrib><creatorcontrib>Bhalla, Kapil</creatorcontrib><creatorcontrib>Kaushik, Jaya Shankar</creatorcontrib><creatorcontrib>Ghalaut, Veena Singh</creatorcontrib><creatorcontrib>Kundu, Zile Singh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gwasikoti, Namita</au><au>Bhalla, Kapil</au><au>Kaushik, Jaya Shankar</au><au>Ghalaut, Veena Singh</au><au>Kundu, Zile Singh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children With Cerebral Palsy</atitle><jtitle>Indian pediatrics</jtitle><stitle>Indian Pediatr</stitle><addtitle>Indian Pediatr</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>58</volume><issue>9</issue><spage>836</spage><epage>838</epage><pages>836-838</pages><issn>0019-6061</issn><eissn>0974-7559</eissn><abstract>Objective
To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin-like growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age- and gender-matched controls.
Methods
A cross-sectional study enrolled 30 children in each group: CP with epilepsy, CP without epilepsy, and healthy controls. Bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.
Results
z-scores of BMD [−1.80 (1.03), −2.12 (0.85) vs −1.40 (0.90);
P
<0.01], 25-OHD levels [19.26 (8.28), 20.59 (8.92) Vs 26.79 (12.76) ng/mL;
P
<0.01] and IGF-1 levels [20.90 (6.42), 23.37 (8.11) vs 31.77 (11.21) ng/mL;
P
<0.01] were significantly low among children with CP with epilepsy, CP without epilepsy when compared to controls.
Conclusion
Children with CP with or without comorbid epilepsy were prone to vitamin D deficiency, low bone mineral density and growth hormone axis suppression with low IGF-1 levels.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>33864451</pmid><doi>10.1007/s13312-021-2303-6</doi><tpages>3</tpages></addata></record> |
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| ispartof | Indian pediatrics, 2021-09, Vol.58 (9), p.836-838 |
| issn | 0019-6061 0974-7559 |
| language | eng |
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| source | Springer Nature; Alma/SFX Local Collection |
| subjects | Bone Density Cerebral Palsy - epidemiology Child Cross-Sectional Studies Humans Insulin-Like Growth Factor I Maternal and Child Health Medicine Medicine & Public Health Pediatric Surgery Pediatrics Research Paper Vitamin D |
| title | Vitamin D, Bone Mineral Density and Serum IGF-1 Level in Non-ambulatory Children With Cerebral Palsy |
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