A systematic review and meta-analysis of ‘Systems for Social Processes’ in borderline personality and substance use disorders

•Social dysfunction underpins Borderline Personality and Substance Use Disorders.•We utilized the NIMH RDoC ‘Systems for Social Processes’ in these groups.•A systematic review and meta-analysis of the published research was conducted.•Overlapping dysfunction across a broad range of constructs was fo...

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Bibliographic Details
Published in:Neuroscience and biobehavioral reviews 2021-08, Vol.127, p.572-592
Main Authors: Hanegraaf, Lauren, van Baal, Simon, Hohwy, Jakob, Verdejo-Garcia, Antonio
Format: Article
Language:English
Subjects:
Attachment
Borderline personality disorder
Emotion recognition
Mental state discrimination
Mentalizing
Ostracism
RDoC
Research and domain criteria
Self-concept
Social cognition
Social communication
Social processing
Substance use disorder
Transdiagnostic
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Summary:•Social dysfunction underpins Borderline Personality and Substance Use Disorders.•We utilized the NIMH RDoC ‘Systems for Social Processes’ in these groups.•A systematic review and meta-analysis of the published research was conducted.•Overlapping dysfunction across a broad range of constructs was found in both groups.•Social processing dysfunction may be a transdiagnostic phenotype of these disorders. Deficits in social processing (SP) have been proposed to underpin interpersonal dysfunction in both Borderline Personality Disorder (BPD) and Substance Use Disorders (SUD). This study aimed to explore potential transdiagnostic cognitive and behavioral phenotypes of these disorders utilizing the NIMH Research Domain Criteria ‘Systems for Social Processes’. A systematic review and meta-analysis of the published research was conducted on 134 studies identified through our database searches. Four meta-analyses were conducted, which revealed significant overlapping deficits in the ability to identify facial emotions and infer the mental states of others in both BPD and SUD. Further, people with BPD displayed a higher ostracism effect following perceived social exclusion. Systematically reviewed studies also revealed significant dysfunction amongst individuals with BPD and SUD across both self and other SP constructs, which were broadly similar in magnitude. Taken together, these results support the proposition that SP dysfunction may be considered a core transdiagnostic phenotype of BPD and SUD.
ISSN:0149-7634
1873-7528
DOI:10.1016/j.neubiorev.2021.04.013