Prevalence of biochemical osteomalacia in adults undergoing vitamin D testing

Objective Prolonged severe vitamin D deficiency can cause osteomalacia, but the 25‐hydroxyvitamin D (25OHD) concentration below which this occurs is unknown. We investigated the prevalence of biochemical osteomalacia in adults with a measurement of 25OHD. Design, Measurement, and Patients 25OHD resu...

Full description

Saved in:
Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2021-07, Vol.95 (1), p.74-83
Main Authors: Bolland, Mark J., Avenell, Alison, Grey, Andrew
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Adult
Alkaline phosphatase
Calcium
Calcium (blood)
deficiency
Humans
Hypercalcemia
hypocalcaemia
Hypocalcemia
insufficiency
Nutrient deficiency
Osteomalacia
Osteomalacia - epidemiology
Parathyroid
Parathyroid Hormone
Prevalence
Supplements
Vitamin D
Vitamin D Deficiency - complications
Vitamin D Deficiency - epidemiology
Vitamin deficiency
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective Prolonged severe vitamin D deficiency can cause osteomalacia, but the 25‐hydroxyvitamin D (25OHD) concentration below which this occurs is unknown. We investigated the prevalence of biochemical osteomalacia in adults with a measurement of 25OHD. Design, Measurement, and Patients 25OHD results between 1/1/2009 and 15/6/2020 were obtained from the regional laboratory database, together with measurements of serum calcium, parathyroid hormone (PTH) and alkaline phosphatase (ALP) within 6 months of the index 25OHD. We defined biochemical osteomalacia as all 3 of: albumin‐adjusted serum calcium (aCa)7.3 pmol/L and ALP>150 IU/L. Possible osteomalacia was 2/3 criteria with the other test not done. 25OHD measurements associated with significant renal impairment, elevated hepatic transaminases or hypercalcaemia were excluded. Results 110,046 25OHD measurements were identified over the 11.5 years period. After removal of ineligible measurements, 42,171 25OHD measurements from 32,386 individuals with at least 2 of aCa, PTH and ALP were included in analyses. Median 25OHD was 63 nmol/L; 8% were
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.14483