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Thermodynamic and structural study of DMPC-alkanol systems
The thermodynamic and structural behaviors of lamellar dimyristoylphosphatidylcholine-alkanol (abbreviation DMPC-C n OH, n = 8-18 is the even number of carbons in the alkyl chain) systems were studied by using DSC and SAXD/WAXD methods at a 0-0.8 C n OH : DMPC molar ratio range. Up to n ≤ 10 a signi...
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| Published in: | Physical chemistry chemical physics : PCCP 2021-04, Vol.23 (14), p.8598-866 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c374t-3ea273200ef826aea6b33279d9b6ca625ce7d98b9a516969a8260a4921648f0f3 |
| container_end_page | 866 |
| container_issue | 14 |
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| container_title | Physical chemistry chemical physics : PCCP |
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| creator | Klacsová, Mária Bóta, Attila Westh, Peter de Souza Funari, Sérgio Uhríková, Daniela Balgavý, Pavol |
| description | The thermodynamic and structural behaviors of lamellar dimyristoylphosphatidylcholine-alkanol (abbreviation DMPC-C
n
OH,
n
= 8-18 is the even number of carbons in the alkyl chain) systems were studied by using DSC and SAXD/WAXD methods at a 0-0.8 C
n
OH : DMPC molar ratio range. Up to
n
≤ 10 a significant biphasic effect depending on the main transition temperature
t
m
on the C
n
OH concentration was observed. Two breakpoints were revealed: turning point (TP), corresponding to the minimum, and threshold concentration (
c
T
), corresponding to the end of the biphasic tendency. These breakpoints were also observed in the alkanol concentration dependent change in the enthalpy of the main transition Δ
H
m
. In the case of C
n
OHs with
n
> 10 we propose a marked shift of TP and
c
T
to very low concentrations; consequently, only increase of
t
m
is observed. A partial phase diagram was constructed for a pseudo-binary DMPC-C12OH system. We suggest a fluid-fluid immiscibility of the DMPC-C12OH system above c
T
with a consequent formation of domains with different C12OH contents. At a constant C
n
OH concentration, the effects of C
n
OHs on Δ
H
m
and bilayer repeat distance were found to depend predominantly on the mismatch between C
n
OH and lipid chain lengths. Observed effects are suggested to be underlined by a counterbalancing effect of interchain van der Waals interactions and headgroup repulsion.
A fluid-fluid immiscibility of the DMPC-C12OH system above threshold concentration with a consequent formation of domains with different C12OH contents is suggested. |
| doi_str_mv | 10.1039/d0cp04991c |
| format | article |
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n
OH,
n
= 8-18 is the even number of carbons in the alkyl chain) systems were studied by using DSC and SAXD/WAXD methods at a 0-0.8 C
n
OH : DMPC molar ratio range. Up to
n
≤ 10 a significant biphasic effect depending on the main transition temperature
t
m
on the C
n
OH concentration was observed. Two breakpoints were revealed: turning point (TP), corresponding to the minimum, and threshold concentration (
c
T
), corresponding to the end of the biphasic tendency. These breakpoints were also observed in the alkanol concentration dependent change in the enthalpy of the main transition Δ
H
m
. In the case of C
n
OHs with
n
> 10 we propose a marked shift of TP and
c
T
to very low concentrations; consequently, only increase of
t
m
is observed. A partial phase diagram was constructed for a pseudo-binary DMPC-C12OH system. We suggest a fluid-fluid immiscibility of the DMPC-C12OH system above c
T
with a consequent formation of domains with different C12OH contents. At a constant C
n
OH concentration, the effects of C
n
OHs on Δ
H
m
and bilayer repeat distance were found to depend predominantly on the mismatch between C
n
OH and lipid chain lengths. Observed effects are suggested to be underlined by a counterbalancing effect of interchain van der Waals interactions and headgroup repulsion.
A fluid-fluid immiscibility of the DMPC-C12OH system above threshold concentration with a consequent formation of domains with different C12OH contents is suggested.</description><identifier>ISSN: 1463-9076</identifier><identifier>EISSN: 1463-9084</identifier><identifier>DOI: 10.1039/d0cp04991c</identifier><identifier>PMID: 33876021</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Chains ; Enthalpy ; Lipids ; Low concentrations ; Miscibility ; Phase diagrams ; Transition temperature</subject><ispartof>Physical chemistry chemical physics : PCCP, 2021-04, Vol.23 (14), p.8598-866</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-3ea273200ef826aea6b33279d9b6ca625ce7d98b9a516969a8260a4921648f0f3</citedby><cites>FETCH-LOGICAL-c374t-3ea273200ef826aea6b33279d9b6ca625ce7d98b9a516969a8260a4921648f0f3</cites><orcidid>0000-0002-1157-4611</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33876021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klacsová, Mária</creatorcontrib><creatorcontrib>Bóta, Attila</creatorcontrib><creatorcontrib>Westh, Peter</creatorcontrib><creatorcontrib>de Souza Funari, Sérgio</creatorcontrib><creatorcontrib>Uhríková, Daniela</creatorcontrib><creatorcontrib>Balgavý, Pavol</creatorcontrib><title>Thermodynamic and structural study of DMPC-alkanol systems</title><title>Physical chemistry chemical physics : PCCP</title><addtitle>Phys Chem Chem Phys</addtitle><description>The thermodynamic and structural behaviors of lamellar dimyristoylphosphatidylcholine-alkanol (abbreviation DMPC-C
n
OH,
n
= 8-18 is the even number of carbons in the alkyl chain) systems were studied by using DSC and SAXD/WAXD methods at a 0-0.8 C
n
OH : DMPC molar ratio range. Up to
n
≤ 10 a significant biphasic effect depending on the main transition temperature
t
m
on the C
n
OH concentration was observed. Two breakpoints were revealed: turning point (TP), corresponding to the minimum, and threshold concentration (
c
T
), corresponding to the end of the biphasic tendency. These breakpoints were also observed in the alkanol concentration dependent change in the enthalpy of the main transition Δ
H
m
. In the case of C
n
OHs with
n
> 10 we propose a marked shift of TP and
c
T
to very low concentrations; consequently, only increase of
t
m
is observed. A partial phase diagram was constructed for a pseudo-binary DMPC-C12OH system. We suggest a fluid-fluid immiscibility of the DMPC-C12OH system above c
T
with a consequent formation of domains with different C12OH contents. At a constant C
n
OH concentration, the effects of C
n
OHs on Δ
H
m
and bilayer repeat distance were found to depend predominantly on the mismatch between C
n
OH and lipid chain lengths. Observed effects are suggested to be underlined by a counterbalancing effect of interchain van der Waals interactions and headgroup repulsion.
A fluid-fluid immiscibility of the DMPC-C12OH system above threshold concentration with a consequent formation of domains with different C12OH contents is suggested.</description><subject>Chains</subject><subject>Enthalpy</subject><subject>Lipids</subject><subject>Low concentrations</subject><subject>Miscibility</subject><subject>Phase diagrams</subject><subject>Transition temperature</subject><issn>1463-9076</issn><issn>1463-9084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpd0c9LwzAUB_AgitPpxbtS8CJC9SWvTRpv0vkLJu4wzyVNU9zsj5m0h_73Zm5O8JRH3ofH4_sIOaNwQwHlbQF6BZGUVO-RIxpxDCUk0f6uFnxEjp1bAgCNKR6SEWIiODB6RO7mH8bWbTE0ql7oQDVF4Drb6663qvJlXwxBWwaT11kaqupTNa3_HVxnandCDkpVOXO6fcfk_fFhnj6H07enl_R-GmoUUReiUUwgAzBlwrgyiueITMhC5lwrzmJtRCGTXKqYcsml8gpUJBnlUVJCiWNytZm7su1Xb1yX1QunTVWpxrS9y1hMY56g4JGnl__osu1t47dbKyZYjCi9ut4obVvnrCmzlV3Uyg4ZhWydaDaBdPaTaOrxxXZkn9em2NHfCD043wDr9K77dxL8BnYNeG4</recordid><startdate>20210414</startdate><enddate>20210414</enddate><creator>Klacsová, Mária</creator><creator>Bóta, Attila</creator><creator>Westh, Peter</creator><creator>de Souza Funari, Sérgio</creator><creator>Uhríková, Daniela</creator><creator>Balgavý, Pavol</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1157-4611</orcidid></search><sort><creationdate>20210414</creationdate><title>Thermodynamic and structural study of DMPC-alkanol systems</title><author>Klacsová, Mária ; Bóta, Attila ; Westh, Peter ; de Souza Funari, Sérgio ; Uhríková, Daniela ; Balgavý, Pavol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-3ea273200ef826aea6b33279d9b6ca625ce7d98b9a516969a8260a4921648f0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chains</topic><topic>Enthalpy</topic><topic>Lipids</topic><topic>Low concentrations</topic><topic>Miscibility</topic><topic>Phase diagrams</topic><topic>Transition temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klacsová, Mária</creatorcontrib><creatorcontrib>Bóta, Attila</creatorcontrib><creatorcontrib>Westh, Peter</creatorcontrib><creatorcontrib>de Souza Funari, Sérgio</creatorcontrib><creatorcontrib>Uhríková, Daniela</creatorcontrib><creatorcontrib>Balgavý, Pavol</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Physical chemistry chemical physics : PCCP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klacsová, Mária</au><au>Bóta, Attila</au><au>Westh, Peter</au><au>de Souza Funari, Sérgio</au><au>Uhríková, Daniela</au><au>Balgavý, Pavol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thermodynamic and structural study of DMPC-alkanol systems</atitle><jtitle>Physical chemistry chemical physics : PCCP</jtitle><addtitle>Phys Chem Chem Phys</addtitle><date>2021-04-14</date><risdate>2021</risdate><volume>23</volume><issue>14</issue><spage>8598</spage><epage>866</epage><pages>8598-866</pages><issn>1463-9076</issn><eissn>1463-9084</eissn><abstract>The thermodynamic and structural behaviors of lamellar dimyristoylphosphatidylcholine-alkanol (abbreviation DMPC-C
n
OH,
n
= 8-18 is the even number of carbons in the alkyl chain) systems were studied by using DSC and SAXD/WAXD methods at a 0-0.8 C
n
OH : DMPC molar ratio range. Up to
n
≤ 10 a significant biphasic effect depending on the main transition temperature
t
m
on the C
n
OH concentration was observed. Two breakpoints were revealed: turning point (TP), corresponding to the minimum, and threshold concentration (
c
T
), corresponding to the end of the biphasic tendency. These breakpoints were also observed in the alkanol concentration dependent change in the enthalpy of the main transition Δ
H
m
. In the case of C
n
OHs with
n
> 10 we propose a marked shift of TP and
c
T
to very low concentrations; consequently, only increase of
t
m
is observed. A partial phase diagram was constructed for a pseudo-binary DMPC-C12OH system. We suggest a fluid-fluid immiscibility of the DMPC-C12OH system above c
T
with a consequent formation of domains with different C12OH contents. At a constant C
n
OH concentration, the effects of C
n
OHs on Δ
H
m
and bilayer repeat distance were found to depend predominantly on the mismatch between C
n
OH and lipid chain lengths. Observed effects are suggested to be underlined by a counterbalancing effect of interchain van der Waals interactions and headgroup repulsion.
A fluid-fluid immiscibility of the DMPC-C12OH system above threshold concentration with a consequent formation of domains with different C12OH contents is suggested.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>33876021</pmid><doi>10.1039/d0cp04991c</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1157-4611</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1463-9076 |
| ispartof | Physical chemistry chemical physics : PCCP, 2021-04, Vol.23 (14), p.8598-866 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_2515683764 |
| source | Royal Society of Chemistry |
| subjects | Chains Enthalpy Lipids Low concentrations Miscibility Phase diagrams Transition temperature |
| title | Thermodynamic and structural study of DMPC-alkanol systems |
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