Prognostic factor identification by screening changes in differentially expressed genes in oral squamous cell carcinoma

Objective This study was designed to identify changes in the expression of proteins occurring during the progression of oral squamous cell carcinoma (OSCC) and to validate their impact on patient prognosis. Materials and Methods The human OSCC cell line UPCI‐SCC‐040 was treated in vitro with TGF‐β1,...

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Published in:Oral diseases 2023-01, Vol.29 (1), p.116-127
Main Authors: Schminke, Boris, Shomroni, Orr, Salinas, Gabriela, Bremmer, Felix, Kauffmann, Philipp, Schliephake, Henning, Oyelami, Felix, Rahat, Michal A., Brockmeyer, Phillipp
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Desaturase
Humans
Lymph nodes
Medical prognosis
Metastases
Mouth Neoplasms - genetics
Mouth Neoplasms - pathology
Oral cancer
Oral carcinoma
Oral squamous cell carcinoma
Prognosis
prognostic factors
sclerostin
SOST protein
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck - genetics
Squamous Cell Carcinoma of Head and Neck - pathology
Stearoyl-CoA Desaturase - genetics
stearoyl‐CoA desaturase‐1
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Summary:Objective This study was designed to identify changes in the expression of proteins occurring during the progression of oral squamous cell carcinoma (OSCC) and to validate their impact on patient prognosis. Materials and Methods The human OSCC cell line UPCI‐SCC‐040 was treated in vitro with TGF‐β1, and transcriptome analysis of differentially expressed genes (DEGs) revealed putative candidates relative to untreated cells. The respective protein expression levels of the most important genes were immunohistochemically validated on a tissue microarray (TMA) containing tissue samples from 39 patients with OSCC and were correlated with disease‐free survival (DFS) as the primary clinical endpoint. Results Our univariate Cox proportional hazard regression (CR) analysis revealed significant correlations among positive N stage (local lymph node metastasis, p = .04), stearoyl‐CoA desaturase‐1 (p 
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.13879