Dynamic Tannic Acid Hydrogel with Self‐Healing and pH Sensitivity for Controlled Release

Dynamic hydrogels constructed with dynamic chemical bonds often have mechanical strength and self‐healing properties. In this paper, tannic acid is combined with lysine‐containing F127 through Schiff base. A series of FLaT hydrogels cross‐linked by hydrogen bonds and dynamic chemical bonds is prepar...

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Bibliographic Details
Published in:Macromolecular bioscience 2021-06, Vol.21 (6), p.e2100055-n/a
Main Authors: Li, Peihong, Sui, Yanlong, Dai, Xueyan, Fang, Qiangsheng, Sima, Haofei, Zhang, Chunling
Format: Article
Language:English
Subjects:
Animals
Bonding strength
Cell Survival - drug effects
Chemical bonds
Controlled release
Cross-Linking Reagents - chemistry
Cytotoxicity
Delayed-Action Preparations - chemistry
Delayed-Action Preparations - pharmacology
Drug delivery
Drug delivery systems
Drug Liberation
drug release
Healing
Humans
hydrogel
Hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
Hydrogen bonding
Hydrogen bonds
Hydrogen-Ion Concentration
Imines
Injectability
Kinetics
Lysine
Mechanical properties
Mice
NIH 3T3 Cells
pH effects
Rheology
Schiff base
Schiff Bases - chemistry
Sensitivity
Sol-gel processes
Structure-Activity Relationship
Tannic acid
Tannins - chemistry
Toxicity
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Summary:Dynamic hydrogels constructed with dynamic chemical bonds often have mechanical strength and self‐healing properties. In this paper, tannic acid is combined with lysine‐containing F127 through Schiff base. A series of FLaT hydrogels cross‐linked by hydrogen bonds and dynamic chemical bonds is prepared, and the influence of Schiff base amount on the performance is discussed. The FLaT hydrogel exhibits reversible sol–gel transition, self‐healing, injectability, and pH sensitivity. Increasing the amount of Schiff base can improve the strength, stability, and self‐healing ability of the hydrogel. Owing to their low cytotoxicity, linear release pattern, and pH‐controlled release rate, the FLaT hydrogels show potential use in drug delivery systems for cancer treatment. The modified tannic acid and FL micelles are cross‐linked by hydrogen bonds and Schiff bases to form FLaT hydrogels. FLaT hydrogel has self‐healing, injectability, temperature and pH sensitivity. FLaT hydrogel is used as a drug release system, showing a linear and stable release pattern within 10 days and a pH‐adjusted release rate.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.202100055