Androgen receptor activation decreases proliferation in thyroid cancer cells

The American Cancer Society predicted more than 52 000 new cases of thyroid cancer in 2020, making it the most prevalent endocrine malignancy. Due to the approximately threefold higher incidence of thyroid cancer in women, we hypothesize that androgens and/or androgen receptors play a protective rol...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2021-09, Vol.122 (9), p.1113-1125
Main Authors: Jones, Melanie E., O'Connell, Timmy J., Zhao, Hong, Darzynkiewicz, Zgibniew, Gupta, Anvita, Buchsbaum, Joseph, Shin, Edward, Iacob, Codrin, Suslina, Nina, Moscatello, Augustine, Schantz, Stimson, Tiwari, Raj, Geliebter, Jan
Format: Article
Language:English
Subjects:
androgen
androgen receptor
Androgen receptors
Androgens
Cancer
Cell cycle
cell cycle checkpoint
Cell proliferation
Cyclin-dependent kinase 2
Cyclin-dependent kinase 4
Malignancy
mRNA
Papillary thyroid cancer
Receptor mechanisms
Receptors
Reduction
Thyroid
Thyroid cancer
Translocation
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Summary:The American Cancer Society predicted more than 52 000 new cases of thyroid cancer in 2020, making it the most prevalent endocrine malignancy. Due to the approximately threefold higher incidence of thyroid cancer in women, we hypothesize that androgens and/or androgen receptors play a protective role and that thyroid cancer in men represents an escape from androgen‐mediated cell regulation. The analysis of androgen receptor (AR) expression in patient tissue samples identified a 2.7‐fold reduction in AR expression (p 
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.29934