Choreographing endo-lysosomal Ca2+ throughout the life of a phagosome

The emergence of endo-lysosomes as ubiquitous Ca2+ stores with their unique cohort of channels has resulted in their being implicated in a growing number of processes in an ever-increasing number of cell types. The architectural and regulatory constraints of these acidic Ca2+ stores distinguishes th...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Molecular cell research 2021-06, Vol.1868 (7), p.119040-119040, Article 119040
Main Authors: Morgan, Anthony J., Davis, Lianne C., Galione, Antony
Format: Article
Language:English
Subjects:
Calcium
Lysosome
Macrophage
NAADP
Phagocytosis
TPC
TRPML
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Summary:The emergence of endo-lysosomes as ubiquitous Ca2+ stores with their unique cohort of channels has resulted in their being implicated in a growing number of processes in an ever-increasing number of cell types. The architectural and regulatory constraints of these acidic Ca2+ stores distinguishes them from other larger Ca2+ sources such as the ER and influx across the plasma membrane. In view of recent advances in the understanding of the modes of operation, we discuss phagocytosis as a template for how endo-lysosomal Ca2+ signals (generated via TPC and TRPML channels) can be integrated in multiple sophisticated ways into biological processes. Phagocytosis illustrates how different endo-lysosomal Ca2+ signals drive different phases of a process, and how these can be altered by disease or infection.
ISSN:0167-4889
1879-2596
DOI:10.1016/j.bbamcr.2021.119040