Endosomal‐lysosomal dysfunctions in Alzheimer’s disease: Pathogenesis and therapeutic interventions

The endosomal-lysosomal system mediates the process of protein degradation through endocytic pathway. This system consists of early endosomes, late endosomes, recycling endosomes and lysosomes. Each component in the endosomal-lysosomal system plays individual crucial role and they work concordantly...

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Bibliographic Details
Published in:Metabolic brain disease 2021-08, Vol.36 (6), p.1087-1100
Main Authors: Lai, Shereen Shi Min, Ng, Khuen Yen, Koh, Rhun Yian, Chok, Kian Chung, Chye, Soi Moi
Format: Article
Language:English
Subjects:
Abnormalities
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Alzheimer's disease
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain - metabolism
Brain - pathology
Degradation
Endosomes
Endosomes - metabolism
Endosomes - pathology
Humans
Lysosomes
Lysosomes - metabolism
Lysosomes - pathology
Metabolic Diseases
Neurodegenerative diseases
Neurology
Neurons - metabolism
Neurons - pathology
Neurosciences
Oncology
Pathogenesis
Protein turnover
Proteins
Proteolysis
Review Article
Therapeutic applications
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Summary:The endosomal-lysosomal system mediates the process of protein degradation through endocytic pathway. This system consists of early endosomes, late endosomes, recycling endosomes and lysosomes. Each component in the endosomal-lysosomal system plays individual crucial role and they work concordantly to ensure protein degradation can be carried out functionally. Dysregulation in the endosomal-lysosomal system can contribute to the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD). In AD endosomal-lysosomal abnormalities are the earliest pathological features to note and hence it is important to understand the involvement of endosomal-lysosomal dysfunction in the pathogenesis of AD. In-depth understanding of this dysfunction can allow development of new therapeutic intervention to prevent and treat AD.
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-021-00737-0