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Endosomal‐lysosomal dysfunctions in Alzheimer’s disease: Pathogenesis and therapeutic interventions

The endosomal-lysosomal system mediates the process of protein degradation through endocytic pathway. This system consists of early endosomes, late endosomes, recycling endosomes and lysosomes. Each component in the endosomal-lysosomal system plays individual crucial role and they work concordantly...

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Published in:	Metabolic brain disease 2021-08, Vol.36 (6), p.1087-1100
Main Authors:	Lai, Shereen Shi Min, Ng, Khuen Yen, Koh, Rhun Yian, Chok, Kian Chung, Chye, Soi Moi
Format:	Article
Language:	English
Subjects:	Abnormalities Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Biochemistry Biomedical and Life Sciences Biomedicine Brain - metabolism Brain - pathology Degradation Endosomes Endosomes - metabolism Endosomes - pathology Humans Lysosomes Lysosomes - metabolism Lysosomes - pathology Metabolic Diseases Neurodegenerative diseases Neurology Neurons - metabolism Neurons - pathology Neurosciences Oncology Pathogenesis Protein turnover Proteins Proteolysis Review Article Therapeutic applications
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container_title	Metabolic brain disease
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creator	Lai, Shereen Shi Min Ng, Khuen Yen Koh, Rhun Yian Chok, Kian Chung Chye, Soi Moi
description	The endosomal-lysosomal system mediates the process of protein degradation through endocytic pathway. This system consists of early endosomes, late endosomes, recycling endosomes and lysosomes. Each component in the endosomal-lysosomal system plays individual crucial role and they work concordantly to ensure protein degradation can be carried out functionally. Dysregulation in the endosomal-lysosomal system can contribute to the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD). In AD endosomal-lysosomal abnormalities are the earliest pathological features to note and hence it is important to understand the involvement of endosomal-lysosomal dysfunction in the pathogenesis of AD. In-depth understanding of this dysfunction can allow development of new therapeutic intervention to prevent and treat AD.
doi_str_mv	10.1007/s11011-021-00737-0
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subjects	Abnormalities Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Biochemistry Biomedical and Life Sciences Biomedicine Brain - metabolism Brain - pathology Degradation Endosomes Endosomes - metabolism Endosomes - pathology Humans Lysosomes Lysosomes - metabolism Lysosomes - pathology Metabolic Diseases Neurodegenerative diseases Neurology Neurons - metabolism Neurons - pathology Neurosciences Oncology Pathogenesis Protein turnover Proteins Proteolysis Review Article Therapeutic applications
title	Endosomal‐lysosomal dysfunctions in Alzheimer’s disease: Pathogenesis and therapeutic interventions
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