Associations of dietary and lifestyle oxidative balance scores with mortality risk among older women: the Iowa Women’s Health Study

Purpose Substantial basic science evidence suggests that oxidative stress may play a role in aging-related health outcomes, including cardiovascular diseases (CVD) and cancer, and oxidative stress markers were linked with all-cause and cause-specific mortality in epidemiologic studies. However, the...

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Bibliographic Details
Published in:European journal of nutrition 2021-10, Vol.60 (7), p.3873-3886
Main Authors: Mao, Ziling, Prizment, Anna E., Lazovich, DeAnn, Bostick, Roberd M.
Format: Article
Language:English
Subjects:
Adipose tissue
Aging
Antioxidants
Cancer
Cardiovascular diseases
Chemistry
Chemistry and Materials Science
Cohort analysis
Epidemiology
Lifestyles
Mortality
Nutrition
Older people
Original Contribution
Oxidants
Oxidative stress
Physical activity
Womens health
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Summary:Purpose Substantial basic science evidence suggests that oxidative stress may play a role in aging-related health outcomes, including cardiovascular diseases (CVD) and cancer, and oxidative stress markers were linked with all-cause and cause-specific mortality in epidemiologic studies. However, the associations of many individual dietary and lifestyle anti-/pro-oxidant exposures with mortality are inconsistent. Oxidative balance scores (OBS) that incorporated multiple dietary and lifestyle factors were previously developed and reported to reflect the collective oxidative effects of multiple exposures. Methods We investigated associations of 11-component dietary and 4-component (physical activity, adiposity, alcohol, and smoking) lifestyle OBS (higher scores were considered more anti-oxidative) with all-cause and cause-specific mortality among women 55–69 years of age at baseline in the prospective Iowa Women’s Health Study (1986–2012). We assessed OBS-mortality associations using multivariable Cox proportional hazards regression. Results Of the 34,137 cancer-free women included in the analytic cohort, 18,058 died (4521 from cancer, and 6825 from CVD) during a mean/median 22.0/26.1 person-years of follow-up. Among participants in the highest relative to the lowest lifestyle OBS quintiles, the adjusted hazards ratios and their 95% confidence intervals for all-cause, all-cancer, and all-CVD mortality were 0.50 (0.48, 0.53), 0.47 (0.43, 0.52), and 0.54 (0.50, 0.58) (all P trend  
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-021-02557-5