Expression of plasma Dickkopf-1 in patients with rheumatoid arthritis and its correlation with peripheral blood T cell subsets

• Published in: Beijing da xue xue bao. Journal of Peking University. Yi xue ban 2020-09, Vol.53 (2), p.255-260
• Main Authors: Cao, D, Wang, Y, Wang, L Q, Sun, X L, Huang, F, Meng, Y, Ren, L L, Zhang, X W
• Format: Article
• Language: Chinese
• Subjects: Arthritis, Rheumatoid; Blood Sedimentation; Humans; Intercellular Signaling Peptides and Proteins - blood; Plasma; Rheumatoid Factor; T-Lymphocyte Subsets
• ISSN: 1671-167X

To detect the levels of Dickkopf-1 (DKK-1) in the plasma of patients with rheumatoid arthritis (RA), and to analyze their correlation with peripheral blood T cell subsets and clinical indicators. Enzyme-linked immunosorbent assay (ELISA) was used to detect plasma DKK-1 levels in 32 RA patients and 20 healthy controls, and to record the various clinical manifestations and laboratory indicators of the RA patients, and flow cytometry to detect peripheral blood T cell subsets in the RA patients (Including Treg, nTreg, aTreg, sTreg, Teff, Tfh, CD4 CD161 T, CD8 T, CD8 CD161 T cells). The plasma DKK-1 levels between the two groups were ompared, and its correlation with peripheral blood T cell subsets and clinical indicators analyzed. (1) The plasma DKK-1 concentration of the RA patients was (124.97±64.98) ng/L. The plasma DKK-1 concentration of the healthy control group was (84.95±13.74) ng/L. The plasma DKK-1 level of the RA patients was significantly higher than that of the healthy control group ( < 0.05), and the