Measuring optic nerve head perfusion to monitor glaucoma: a study on structure–function relationships using laser speckle flowgraphy

Purpose We aimed to describe the global and localized correlations among visual field (VF) sensitivity, optic nerve head (ONH) perfusion measured by laser speckle flowgraphy (LSFG) and neural structure measured by optical coherence tomography (OCT) in open‐angle glaucoma (OAG) and to compare the flo...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2022-02, Vol.100 (1), p.e181-e191
Main Authors: Calzetti, Giacomo, Mursch‐Edlmayr, Anna Sophie, Bata, Ahmed M., Ungaro, Nicola, Mora, Paolo, Chua, Jacqueline, Schmidl, Doreen, Bolz, Matthias, Garhöfer, Gerhard, Gandolfi, Stefano, Schmetterer, Leopold, Wong, Damon
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Breakpoints
Cross-Sectional Studies
Female
floor effect
Glaucoma
Glaucoma, Open-Angle - diagnosis
Glaucoma, Open-Angle - physiopathology
Humans
Intraocular Pressure - physiology
laser speckle flowgraphy
Lasers
Male
Middle Aged
Monitoring, Physiologic - methods
Nerve Fibers - pathology
Optic Disk - blood supply
Optic nerve
optical coherence tomography
Perfusion
Regional Blood Flow - physiology
Retinal Ganglion Cells - pathology
Structure-Activity Relationship
Structure-function relationships
structure–function
Tomography, Optical Coherence - methods
Visual field
Visual Fields - physiology
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Summary:Purpose We aimed to describe the global and localized correlations among visual field (VF) sensitivity, optic nerve head (ONH) perfusion measured by laser speckle flowgraphy (LSFG) and neural structure measured by optical coherence tomography (OCT) in open‐angle glaucoma (OAG) and to compare the floor effect for LSFG and OCT. Methods Cross‐sectional, multicenter study including one eye each from fifty OAG patients (mean age 69.3 years; average VF mean deviation, MD, −8.5 dB, range −25.17 to 0.85 dB) and fifty‐one controls. Patients underwent SITA standard 24‐2 automated perimetry and measurement of ONH perfusion, peripapillary retinal nerve fibre layer thickness (RNFLT) and macular ganglion cell‐inner plexiform layer thickness (GCIPLT). We tested the presence of a significant change (breakpoint) in the correlation slope with VF sensitivity to assess floor effect. Results The correlation between the LSFG parameter Mean All (MA) of the global disc area and MD (r = 0.56, p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.14862