Success and risks of pregnancy after breast cancer

Introduction Breast cancer is the most common cancer in women worldwide. The number of childbearing-age women diagnosed with early breast cancer (eBC) is increasing, raising questions over their subsequent fertility. Purpose The main objective of this study was therefore to assess, in a cohort of eB...

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Bibliographic Details
Published in:Breast cancer research and treatment 2021-08, Vol.188 (3), p.593-600
Main Authors: Leproux, Chloe, Seegers, Valerie, Patsouris, Anne, Sauterey, Baptiste
Format: Article
Language:English
Subjects:
Adolescent
Adult
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - therapy
Cancer research
Care and treatment
Clinical Trial
Female
Fertility
Humans
Live Birth - epidemiology
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Neoplasm Recurrence, Local
Oncology
Patients
Pregnancy
Pregnancy Outcome - epidemiology
Pregnant women
Reproductive Techniques, Assisted
Reproductive technologies
Retrospective Studies
Survival
Womens health
Young Adult
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Summary:Introduction Breast cancer is the most common cancer in women worldwide. The number of childbearing-age women diagnosed with early breast cancer (eBC) is increasing, raising questions over their subsequent fertility. Purpose The main objective of this study was therefore to assess, in a cohort of eBC patients with pregnancy desire, the rate of live births achieved spontaneously or by assisted reproductive technology. Methods We conducted an observational, descriptive, retrospective study including patients aged 18–40, treated for eBC at the Institut de Cancérologie de l’Ouest (ICO) Pays de Loire between July 2010 and July 2016, with pregnancy desire. The primary outcome was the rate of live births. Secondary outcomes were overall survival, disease-free survival, time to conception, and spontaneous or assisted pregnancy rate. Results 61 patients were included, with a live birth rate of 19.7% (12/61). We observed no recurrence or death in women with a pregnancy. Pregnancy started with a median time of 36.4 months after the end of treatment (4.1–51.3 months). All pregnancies in this cohort were achieved spontaneously. Conclusion The results of our cohort are consistent with previous results showing that spontaneous pregnancy remains possible after treatment for eBC without increasing the risk of recurrence or death.
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-021-06232-5