Compassionate Use of Remdesivir in Children With Severe COVID-19

Remdesivir shortens time to recovery in adults with severe coronavirus disease 2019 (COVID-19), but its efficacy and safety in children are unknown. We describe outcomes in children with severe COVID-19 treated with remdesivir. Seventy-seven hospitalized patients

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Bibliographic Details
Published in:Pediatrics (Evanston) 2021-05, Vol.147 (5), p.1
Main Authors: Goldman, David L, Aldrich, Margaret L, Hagmann, Stefan H F, Bamford, Alasdair, Camacho-Gonzalez, Andres, Lapadula, Giuseppe, Lee, Philip, Bonfanti, Paolo, Carter, Christoph C, Zhao, Yang, Telep, Laura, Pikora, Cheryl, Naik, Sarjita, Marshall, Neal, Katsarolis, Ioannis, Das, Moupali, DeZure, Adam, Desai, Polly, Cao, Huyen, Chokkalingam, Anand P, Osinusi, Anu, Brainard, Diana M, Méndez-Echevarría, Ana
Format: Article
Language:English
Subjects:
Adenosine Monophosphate - adverse effects
Adenosine Monophosphate - analogs & derivatives
Adenosine Monophosphate - therapeutic use
Adolescent
Adverse events
Alanine - adverse effects
Alanine - analogs & derivatives
Alanine - therapeutic use
Antiviral Agents - adverse effects
Antiviral Agents - therapeutic use
Antiviral drugs
Child
Child, Preschool
Children
Comorbidity
Compassionate Use Trials
Coronaviridae
Coronaviruses
COVID-19
COVID-19 - diagnosis
COVID-19 - drug therapy
Diseases
Drug Therapy, Combination
Female
Hospitalization
Humans
Infant
Male
Mechanical ventilation
Oxygen
Oxygen Inhalation Therapy
Patients
Pediatric diseases
Pediatrics
Remdesivir
Respiration, Artificial
SARS-CoV-2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Transaminase
Treatment Outcome
Ventilation
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Description
Summary:Remdesivir shortens time to recovery in adults with severe coronavirus disease 2019 (COVID-19), but its efficacy and safety in children are unknown. We describe outcomes in children with severe COVID-19 treated with remdesivir. Seventy-seven hospitalized patients
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2020-047803