The combined use of systemic analgesic/anti-inflammatory drugs and a bioactive topical desensitizer for reduced in-office bleaching sensitivity without jeopardizing the hydrogen peroxide efficacy: a randomized, triple blinded, split-mouth clinical trial

Objective To evaluate the effect of combined systemic administration of paracetamol 500 mg/codeine phosphate 30 mg (PACO) and postoperative topical application of a bioactive desensitizer on in-office bleaching sensitivity and tooth color change. Materials and methods A randomized, triple-blind, spl...

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Bibliographic Details
Published in:Clinical oral investigations 2021-12, Vol.25 (12), p.6623-6632
Main Authors: de Araújo, Isabela Dantas Torres, de Sousa Santos, Kaiza, das Neves Peixoto, Thauan Victor Oliveira, Costa, Moan Jéfter Fernandes, de Assunção, Isauremi Vieira, Borges, Boniek Castillo Dutra
Format: Article
Language:English
Subjects:
Analgesics
Anti-inflammatory agents
Bleaching
Clinical trials
Codeine
Color
Dentistry
Hydrogen peroxide
Inflammation
Medicine
Mouth
Original Article
Paracetamol
Topical application
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Summary:Objective To evaluate the effect of combined systemic administration of paracetamol 500 mg/codeine phosphate 30 mg (PACO) and postoperative topical application of a bioactive desensitizer on in-office bleaching sensitivity and tooth color change. Materials and methods A randomized, triple-blind, split-mouth clinical trial was conducted. Forty volunteers ingested PACO ( n  = 20) or placebo (PLA) ( n  = 20). Their left/right hemiarches received topical application of a bioactive desensitizer [Nano-P™(NP)] and prophylactic paste (PAS), generating four treatment approaches: PACO/NP, PACO/PAS, PLA/NP, and PLA/PAS. Two bleaching sessions (35% hydrogen peroxide) were performed, and the PAS/NP were applied after the procedure. Sensitivity was obtained since the first bleaching session up to 7 days post-bleaching. The color change was evaluated using CIEDE2000 and whiteness index parameters up to 7 days post-bleaching. Data were analyzed using one- and two-way ANOVA/Tukey post hoc tests ( p   0.05) . Conclusion The combined approach of systemic administration of PACO and postoperative topical application of NP reduced the level of in-office bleaching sensitivity without jeopardizing hydrogen peroxide efficacy. Clinical relevance Professionals can adopt the combined approach of systemic administration of analgesic/anti-inflammatory drugs and topical application of a bioactive desensitizer for decreased bleaching sensitivity caused by 35% hydrogen peroxide in-office.
ISSN:1432-6981
1436-3771
DOI:10.1007/s00784-021-03948-y