Berberine carried gelatin/sodium alginate hydrogels with antibacterial and EDTA-induced detachment performances

• Published in: International journal of biological macromolecules 2021-06, Vol.181, p.1039-1046
• Main Authors: Zhang, Xiumei, Miao, Fenyan, Niu, Lulu, Wei, Yan, Hu, Yinchun, Lian, Xiaojie, Zhao, Liqin, Chen, Weiyi, Huang, Di
• Format: Article
• Language: English
• Subjects: Detachment; Drug carried; Hydrogels
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2021.04.114

Most existing hydrogel wound dressings lack gentle detachment property. In this work, novel hydrogels with anti-bacterial and induced detachment properties were prepared. Both gelatin (G) and sodium alginate (SA) are natural polymer materials. The G/SA hydrogels were prepared by dual cross-linking. The addition of SA significantly improves the mechanical properties of composite hydrogels. The tensile modulus and elongation at break of the G/SA hydrogels with 2.0% SA could reach 99.23 ± 2.18 kPa and 85.47 ± 5.01%, respectively. In addition, the interconnected porous network and high swelling ratio (over 9.99 ± 0.33) are beneficial to the transmission of oxygen and absorption of exudates to accelerate the healing of wound. Subsequently, berberine (BBR) was loaded into the G/SA hydrogels. The BBR/G/SA hydrogels show sustained drug release for 168 h and exhibit anti-bacterial effect against Staphylococcus aureus. The results of L929 cells cultured with the hydrogel extracts indicate good biocompatibility. Finally, results of EDTA-induced detachment performances demonstrate that the hydrogels could be removed from the wound as the internal structure destroyed. All illustrated results above demonstrated the BBR carried G/SA hydrogels have potential used as wound dressing materials in future. •Developed the G/SA hydrogels based on mTG/Ca2+ dual cross-linking, which is an easy, fast, nontoxic and cost-less method.•The drug release time could be adjusted by varying BBR content in BBR/G/SA hydrogels.•The G/SA hydrogels possess EDTA-induced detachment performance.•The drug carried G/SA hydrogels show potential for clinical wound healing application.