Neuropsychological performance in youth with obsessive-compulsive disorder

There is a paucity of literature on neuropsychological functions in youth with obsessive-compulsive disorder (OCD). Most studies have small sample sizes and have yielded inconsistent results. A recent meta-analysis failed to identify any significant impairments. We studied neuropsychological functio...

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Bibliographic Details
Published in:Journal of psychiatric research 2021-06, Vol.138, p.301-310
Main Authors: Deepthi, K., Roopesh, Bangalore N., Balachander, Srinivas, Vijay Sagar, John K., Kandavel, Thennarasau, Reddy, Y.C.Janardhan
Format: Article
Language:English
Subjects:
Adolescents
Children
Executive functions
Neuropsychology
Obsessive-compulsive disorder
Youth
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Summary:There is a paucity of literature on neuropsychological functions in youth with obsessive-compulsive disorder (OCD). Most studies have small sample sizes and have yielded inconsistent results. A recent meta-analysis failed to identify any significant impairments. We studied neuropsychological functions (attention, verbal fluency, working memory, set-shifting, response inhibition, planning and visuospatial abilities) in a large sample of youth with OCD (n = 97) in comparison with controls who did not have OCD (n = 50). After controlling for the confounding effects (age, sex, severity of depression and anxiety, presence of comorbid attention-deficit hyperactivity disorder, any tic disorder, number of comorbidities, and non-verbal intelligence measured by the standard progressive matrices), the youth with OCD significantly underperformed with large effect sizes compared to controls, only on the test of ‘behavioral reversal’, measured by the Object Alternation Test (trials to reach criterion p 
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2021.03.066