MiRNA-124a: a Potential Biomarker for Neurological Deficits Following Cardiac Surgery in Pediatric Patients

Brain injury is a major source of patient morbidity after cardiac surgery in children. New early accurate biomarkers are needed for the diagnosis of patients at risk for cerebral postoperative damage. Specific circulating miRNAs have been found as suitable biomarkers for many diseases. We tested whe...

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Bibliographic Details
Published in:Journal of cardiovascular translational research 2021-12, Vol.14 (6), p.1165-1172
Main Authors: Zloto, Keren, Mor, Liat, Bar-Yosef, Omer, Tirosh-Wagner, Tal, Vardi, Amir, Mishali, David, Paret, Gideon, Nevo-Caspi, Yael
Format: Article
Language:English
Subjects:
Biomarkers - blood
Biomedical Engineering and Bioengineering
Biomedicine
Brain Diseases - blood
Brain Diseases - etiology
Cardiac Surgical Procedures
Cardiology
Child
Child, Preschool
Circulating MicroRNA - blood
Female
Human Genetics
Humans
Infant
Infant, Newborn
Male
Medicine
Medicine & Public Health
Original Article
Postoperative Complications - blood
Postoperative Complications - etiology
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Summary:Brain injury is a major source of patient morbidity after cardiac surgery in children. New early accurate biomarkers are needed for the diagnosis of patients at risk for cerebral postoperative damage. Specific circulating miRNAs have been found as suitable biomarkers for many diseases. We tested whether miRNA-124a reflects neurological injury in pediatric patients following heart surgery. Serum samples were obtained from 34 patients before and six hours after heart surgery. MiRNAs-124a was quantified by RQ-PCR. MiRNA-124a levels six hours after heart surgery correlated with the neurological outcome of the patients. In children with neurological deficits, miRNA-124a levels increased while in those with no neurological deficits the levels decreased. MiRNA-124a was able, at six hours after the operation, to identify patients who are at risk for the appearance of neurological deficits. Circulating miRNA-124a is a potential biomarker for the appearance of neurological deficits in pediatric patients following heart surgery. Graphical Abstract
ISSN:1937-5387
1937-5395
DOI:10.1007/s12265-021-10127-7