Uterine natural killer cells and recurrent spontaneous abortion

Recurrent spontaneous abortion (RSA), termed as two or more consecutive pregnancy loss is a great problem for some women of childbearing age. A large number of evidence confirm that there may be an immune background of RSA. As a member of the innate immune system, uterine natural killer (uNK) cells...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2021-08, Vol.86 (2), p.e13433-n/a
Main Authors: Fu, Yao‐Yao, Ren, Chun‐E., Qiao, Peng‐Yun, Meng, Yu‐Han
Format: Article
Language:English
Subjects:
Abortion, Habitual - immunology
CD56brightCD56dim
Female
Humans
Immune system
Innate immunity
Killer Cells, Natural - immunology
Lymphocytes
Miscarriage
Natural killer cells
Phenotypes
Pregnancy
recurrent spontaneous abortion
uterine NK cells
Uterus
Uterus - immunology
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Summary:Recurrent spontaneous abortion (RSA), termed as two or more consecutive pregnancy loss is a great problem for some women of childbearing age. A large number of evidence confirm that there may be an immune background of RSA. As a member of the innate immune system, uterine natural killer (uNK) cells account for about 70% of total lymphocytes during pregnancy and play a critical role in the establishment and maintenance of pregnancy. This review mainly introduces the phenotype, origin, receptor, and function of uNK cells to illuminate its relationship with RSA.
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.13433