Serum calprotectin (S100A8/A9) levels as a new potential biomarker of treatment response in Hodgkin lymphoma

• Published in: International journal of laboratory hematology 2021-08, Vol.43 (4), p.638-644
• Main Authors: Şumnu, Şeyma, Mehtap, Özgür, Mersin, Sinan, Toptaş, Tayfur, Görür, Gözde, Gedük, Ayfer, Ünal, Serkan, Polat, Merve Gökçen, Aygün, Kemal, Yenihayat, Emel Merve, Albayrak, Hayrunnisa, Uluköylü Mengüç, Meral, Tarkun, Pınar, Hacıhanifioğlu, Abdullah
• Format: Article
• Language: English
• Subjects: biomarker; Biomarkers; calprotectin; Computed tomography; Hodgkin lymphoma; Hodgkin's lymphoma; Inflammation; Lymphoma; Patients; Positron emission tomography; S100A8/A9; Tomography; Tumorigenesis
• ISSN: 1751-5521; 1751-553X
• DOI: 10.1111/ijlh.13559

Introduction Hodgkin lymphoma (HL) is unusual among malignancies, with inflammation playing such a prominent role in its pathogenesis. S100A8/A9 (calprotectin) is a heterodimeric protein, which has a role in the inflammatory response and oncogenesis. In this study in HL patients, the correlation between serum S100A8/A9 levels and treatment responses was investigated along with whether this marker is correlated with other inflammatory markers. Materials and Methods Thirty‐three HL patients and 20 healthy volunteers were included. Demographic and clinical characteristics were recorded. Calprotectin levels were measured with Human S100A8/A9 Heterodimer Quantikine ELISA kit. Calprotectin levels were measured twice in patients, before and after treatment, and once in the control group. Treatment responses were evaluated with positron emission tomography‐computed tomography (PET‐CT). Results The mean age of patients was 44.3 ± 18.1 (66.3% male). The median (IQR) values of S100A8/A9 before and after treatment in the patient group were 4.98 (2.6‐7.8) and 1.87 (1.1‐4.8)µg/mL. Median (IQR) S100A8/A9 concentration in the control group was 1.41 (0.98‐2.73)µg/mL. In patients, pretreatment values were significantly higher than in controls (P