Genetics in Drug Discovery

Drug discovery is a complex process with high attrition rate: only about half of the compounds in advanced preclinical stages actually enter human trials. Key to these failures is our lack of understanding of human biology and the difficulties in translating our preclinical knowledge into cures. Her...

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Bibliographic Details
Published in:Trends in genetics 2021-07, Vol.37 (7), p.603-605
Main Authors: Hubaud, Alexis, Singh, Ajeet Pratap
Format: Article
Language:English
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Summary:Drug discovery is a complex process with high attrition rate: only about half of the compounds in advanced preclinical stages actually enter human trials. Key to these failures is our lack of understanding of human biology and the difficulties in translating our preclinical knowledge into cures. Here, we examine how genetics can be leveraged in drug discovery to understand and alter human biology.
ISSN:0168-9525
DOI:10.1016/j.tig.2021.04.001