Amino acid–functionalized carbon quantum dots for selective detection of Al3+ ions and fluorescence imaging in living cells

Carbon quantum dots (CQDs) are drawing tremendous attention due to their unique photoluminescence property and fascinating functions. Herein, we prepared novel CQDs functionalized with amino acids (AA-CQDs) by a one-pot hydrothermal method for selective detection of Al 3+ ions and fluorescence imagi...

Full description

Saved in:
Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2021-06, Vol.413 (15), p.3965-3974
Main Authors: Yan, Chaoren, Guo, Liulong, Shao, Xu, Shu, Qi, Guan, Ping, Wang, Jingwei, Hu, Xiaoling, Wang, Chaoli
Format: Article
Language:English
Subjects:
Aluminum
Amino acids
Analytical Chemistry
Apoptosis
Biochemistry
Biocompatibility
Biosensors
Carbon
Cells (biology)
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Endocytosis
Fluorescence
Food Science
Ions
Laboratory Medicine
Monitoring/Environmental Analysis
Photoluminescence
Photons
Quantum dots
Research Paper
Selectivity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Carbon quantum dots (CQDs) are drawing tremendous attention due to their unique photoluminescence property and fascinating functions. Herein, we prepared novel CQDs functionalized with amino acids (AA-CQDs) by a one-pot hydrothermal method for selective detection of Al 3+ ions and fluorescence imaging. The prepared AA-CQDs exhibit a novel triple-excitation and single-colour emission for fluorescent property. In addition, the AA-CQDs have a high absolute quantum yield (24.23%) and quantum lifetime (13.29 ns). Moreover, the AA-CQDs exhibit high selectivity and sensitivity for Al 3+ by fluorescence enhancement. In pH 7.4 PBS solution, there was a good linear relation between the fluorescence intensity and the concentration of Al 3+ in the range of 1–20 μmol L −1 ; the limit of detection (3σ) was only 0.32 μmol L −1 . Furthermore, an AA-CQD probe was also utilized for detection of Al 3+ in living cells based on excellent biocompatibility and endocytosis. Based on the concentration of Al 3+ ions in cells and apoptosis data, there will be a quick reflect of apoptosis induced by aluminium ions via the fluorescence intensity of the AA-CQD probe. This work will set the stage for developing novel CQD-based biosensors in cell research. Graphical abstract
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-021-03348-x