Mitochondria targeted near-infrared chemodosimeter for upconversion luminescence bioimaging of hypoxia

We report a mitochondria-targeted near-infrared probe (NRh-O) for frequency upconversion luminescence (FUCL) imaging of hypoxia. Under hypoxic conditions, NRh-O rapidly responds to release the FUCL product NRh ( λ ex/em = 850/825 nm) with high sensitivity and selectivity in mitochondria. This highli...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-05, Vol.57 (42), p.527-521
Main Authors: Yu, Hui, Sun, Wanlu, Tiemuer, Aliya, Zhang, Yuanyuan, Wang, Hai-Yan, Liu, Yi
Format: Article
Language:English
Subjects:
Hypoxia
Luminescence
Medical imaging
Mitochondria
Selectivity
Upconversion
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Summary:We report a mitochondria-targeted near-infrared probe (NRh-O) for frequency upconversion luminescence (FUCL) imaging of hypoxia. Under hypoxic conditions, NRh-O rapidly responds to release the FUCL product NRh ( λ ex/em = 850/825 nm) with high sensitivity and selectivity in mitochondria. This highlights the potential application of a hypoxia-responsive probe in early clinical diagnosis. A novel frequency upconversion luminescence chemodosimeter is capable of specially targeting mitochondria and monitoring tumor hypoxia in vivo .
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc01338f