Effects of Acute Coronary Syndrome and Stable Coronary Artery Disease on Bleeding and Ischemic Risk After Percutaneous Coronary Intervention

Background:Data evaluating the effects of acute coronary syndrome (ACS) relative to stable coronary artery disease (CAD) on bleeding risk after percutaneous coronary intervention (PCI) are scarce.Methods and Results:From the CREDO-Kyoto Registry Cohort-3, 13,258 patients undergoing first PCI (5,521...

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Bibliographic Details
Published in:Circulation Journal 2021/10/25, Vol.85(11), pp.1928-1941
Main Authors: Natsuaki, Masahiro, Morimoto, Takeshi, Shiomi, Hiroki, Kadota, Kazushige, Tada, Tomohisa, Takeji, Yasuaki, Matsumura-Nakano, Yukiko, Yoshikawa, Yusuke, Watanabe, Hirotoshi, Yamamoto, Ko, Imada, Kazuaki, Domei, Takenori, Yamaji, Kyohei, Kaneda, Kazuhisa, Taniguchi, Ryoji, Ehara, Natsuhiko, Nawada, Ryuzo, Toyofuku, Mamoru, Shinoda, Eiji, Suwa, Satoru, Tamura, Toshihiro, Inada, Tsukasa, Matsuda, Mitsuo, Aoyama, Takeshi, Sato, Yukihito, Furukawa, Yutaka, Ando, Kenji, Nakagawa, Yoshihisa, Kimura, Takeshi, for the CREDO-Kyoto PCI/CABG Registry Cohort-3 Investigators
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Acute Coronary Syndrome - therapy
Coronary Artery Disease - complications
Coronary Artery Disease - surgery
Hemorrhage - etiology
High bleeding risk
Humans
Ischemic Stroke
Myocardial Infarction
Percutaneous coronary intervention
Percutaneous Coronary Intervention - adverse effects
Platelet Aggregation Inhibitors
Risk Factors
Treatment Outcome
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Summary:Background:Data evaluating the effects of acute coronary syndrome (ACS) relative to stable coronary artery disease (CAD) on bleeding risk after percutaneous coronary intervention (PCI) are scarce.Methods and Results:From the CREDO-Kyoto Registry Cohort-3, 13,258 patients undergoing first PCI (5,521 ACS; 7,737 stable CAD) were identified. Patients were further stratified according to ACS presentation and Academic Research Consortium High Bleeding Risk (HBR): ACS/HBR: n=2,502; ACS/no-HBR: n=3,019; stable CAD/HBR: n=3,905; and stable CAD/no-HBR: n=3,832. The primary bleeding endpoint was Bleeding Academic Research Consortium 3/5 bleeding, whereas the primary ischemic endpoint was myocardial infarction (MI)/ischemic stroke. Compared with stable CAD, ACS was associated with a significantly higher adjusted risk for bleeding (hazard ratio [HR] 1.85; 95% confidence interval [CI] 1.68–2.03; P
ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-21-0016