Hypoglobulinemia in a dog with disseminated plasma cell neoplasia: Case report and review of the diagnostic criteria

This is the first reported case of hypoglobulinemia in a dog with disseminated plasma cell neoplasia. A 6‐year‐old male intact Rottweiler was referred to the U‐Vet Animal Hospital (Werribee, Vic, Australia) for weight loss, hyporexia, lethargy, vomiting, and soft stools. Examination of a buffy coat...

Full description

Saved in:
Bibliographic Details
Published in:Veterinary clinical pathology 2021-06, Vol.50 (2), p.227-235
Main Authors: Brown, Juliet E., Russell, Elise B., Moore, A. Russell, Oscos‐Snowball, Astrid, Stent, Andrew, Courtman, Natalie F.
Format: Article
Language:English
Subjects:
bone marrow
canine
Case reports
electrophoresis
immunofixation
nonsecretory
plasma cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This is the first reported case of hypoglobulinemia in a dog with disseminated plasma cell neoplasia. A 6‐year‐old male intact Rottweiler was referred to the U‐Vet Animal Hospital (Werribee, Vic, Australia) for weight loss, hyporexia, lethargy, vomiting, and soft stools. Examination of a buffy coat preparation and splenic and liver aspirates revealed a monomorphic population of plasmacytoid cells, and the same cells comprised approximately 90% of bone marrow samples submitted for cytologic and histologic evaluation. Biochemistry revealed a hypoglobulinemia, and the presence of an M‐protein was not supported by serum and urine protein electrophoresis or serum immunofixation. Immunohistochemistry demonstrated strong nuclear labeling for MUM‐1.
ISSN:0275-6382
1939-165X
DOI:10.1111/vcp.12948