Simulation study of spinal cord stimulation evoked compound action potential

Spinal cord stimulation (SCS) for pain is usually implanted as an open loop system using unchanged parameters. To avoid the under and over stimulation caused by lead migration, evoked compound action potentials (ECAP) is used as feedback signal to change the stimulating parameters. This study establ...

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Bibliographic Details
Published in:Sheng wu yi xue gong cheng xue za zhi 2021-04, Vol.38 (2), p.232-240
Main Authors: Zhang, Guanghao, Zhang, Cheng, Wu, Changzhe, Huo, Xiaolin
Format: Article
Language:Chinese
Subjects:
Action potential
Action Potentials
Amplitudes
Computer Simulation
Electric Stimulation
Evoked Potentials
Excitation
Fibers
Finite element method
Mathematical models
Pain
Parameters
Simulation
Spinal Cord
Spinal Cord Stimulation
Stimulation
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Summary:Spinal cord stimulation (SCS) for pain is usually implanted as an open loop system using unchanged parameters. To avoid the under and over stimulation caused by lead migration, evoked compound action potentials (ECAP) is used as feedback signal to change the stimulating parameters. This study established a simulation model of ECAP recording to investigate the relationship between ECAP component and dorsal column (DC) fiber recruitment. Finite element model of SCS and multi-compartment model of sensory fiber were coupled to calculate the single fiber action potential (SFAP) caused by single fiber in different spinal cord regions. The synthetized ECAP, superimposition of SFAP, could be considered as an index of DC fiber excitation degree, because the position of crests and amplitude of ECAP corresponds to different fiber diameters. When 10% or less DC fibers were excited, the crests corresponded to fibers with large diameters. When 20% or more DC fibers were excited, ECAP showed a slow conduction crest, which c
ISSN:1001-5515
DOI:10.7507/1001-5515.202007016