Effect of adjuvant therapy on the prognosis in stage I/II uterine carcinosarcoma: A meta‐analysis

Introduction To assess the efficacy of adjuvant chemotherapy, radiotherapy, or both following the primary surgery on the progression‐free survival and 5‐year overall survival in patients with stage I/II uterine carcinosarcoma. Methods A preliminary investigation was conducted using PubMed and Embase...

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Published in:The journal of obstetrics and gynaecology research 2021-07, Vol.47 (7), p.2473-2480
Main Authors: Zhao, Fei, Tan, Ping, Wang, Chang, Ji, Xuechao, Chen, Aiping
Format: Article
Language:English
Subjects:
5‐year overall survival
Adjuvant therapy
Chemoradiotherapy
Chemotherapy
Medical prognosis
Meta-analysis
progression‐free survival
Radiation therapy
Surgery
Survival
uterine carcinosarcoma
Uterus
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Summary:Introduction To assess the efficacy of adjuvant chemotherapy, radiotherapy, or both following the primary surgery on the progression‐free survival and 5‐year overall survival in patients with stage I/II uterine carcinosarcoma. Methods A preliminary investigation was conducted using PubMed and Embase databases to identify relevant studies published up to March, 2020. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated by Revman 5.3 software to analysis outcomes. Results Six retrospective cohort studies were involved in the analysis, including 1516 patients in observation group, 956 patients in chemotherapy group, 750 patients in radiotherapy group, and 1082 patients in raidochemotherapy group. The results indicated that chemotherapy alone (HR = 0.59, 95% CI = 0.38–0.91, p 
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.14800