Synthesis of NNN Chiral Ruthenium Complexes and Their Cytotoxicity Studies

The synthesis and characterization of chiral pincer-ruthenium complexes of the type (R2NNN)­RuCl2 (PPh3) (R = 3-methylbutyl and 3,3-dimethylbutyl) is reported here. The cytotoxicity studies of these complexes were studied and compared with the corresponding activity of achiral complexes. The cytotox...

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Published in:Inorganic chemistry 2021-05, Vol.60 (10), p.7422-7432
Main Authors: Nandi, Pran Gobinda, Jadi, Praveen Kumar, Das, Kanu, Prathapa, Siriyara Jagannatha, Mandal, Biman B, Kumar, Akshai
Format: Article
Language:English
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Summary:The synthesis and characterization of chiral pincer-ruthenium complexes of the type (R2NNN)­RuCl2 (PPh3) (R = 3-methylbutyl and 3,3-dimethylbutyl) is reported here. The cytotoxicity studies of these complexes were studied and compared with the corresponding activity of achiral complexes. The cytotoxic effect of pincer-ruthenium complexes on human dermal fibroblasts and human tongue carcinoma cells assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay displayed an inhibition of normal and cancer cell growth in a dose-dependent manner. Intracellular reactive oxygen species (ROS) level measurement, lactate dehydrogenase assay, DNA fragmentation, and necrosis studies revealed that treatment with pincer-ruthenium complexes induced a redox imbalance in SAS cells by upregulating ROS generation and caused necrotic cell death by disrupting the cellular membrane integrity.
ISSN:0020-1669
1520-510X
DOI:10.1021/acs.inorgchem.1c00698