Respiratory characteristics of the tammar wallaby pouch young and functional limitations in a newborn with skin gas exchange

• Published in: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology Biochemical, systemic, and environmental physiology, 2021-11, Vol.191 (6), p.995-1006
• Main Authors: MacFarlane, P. M., Frappell, P. B., Haase, T.
• Format: Article
• Language: English
• Subjects: 2,4-Dinitrophenol; Animal Physiology; Animals; Animals, Newborn; Biochemistry; Biomedical and Life Sciences; Biomedicine; Birth weight; Carbon dioxide; Convection; Gas exchange; Human Physiology; Hyperventilation; Hypometabolism; Hypoxia; Life Sciences; Low birth weight; Lung; Macropodidae; Marsupials; Metabolism; Neonates; Original Paper; Oxygen demand; Pulmonary Gas Exchange; Respiratory Physiological Phenomena; Respiratory system; Skin; Untangling the Oxygen Transport Cascade: A tribute to Peter Frappell (“Frapps”); Ventilatory behavior; Zoology
• ISSN: 0174-1578; 1432-136X
• DOI: 10.1007/s00360-021-01364-y

A short gestation, low birth weight and presence of cutaneous exchange of O 2 and CO 2 comprise altricial features of newborn marsupials and that collectively implies a highly immature respiratory system. In the present study, we investigated various respiratory characteristics of the neonatal/postnatal tammar wallaby, a species of marsupial in which > 30% of the newborn’s total O 2 demands are supported by cutaneous rather than pulmonary gas exchange. The ventilatory response (HVR) to acute hypoxia (10% inspired O 2 ) was absent in the newborn (1 day old) pouch young; a hypoxic hypometabolism contributed entirely to the hyperventilation (increased pulmonary convection requirement). A high (compared to older animals) resting metabolic cost to breathe and an inefficient respiratory system suggest the lack of a HVR might be due to an energetic constraint that impinges on their ability to sustain an increase in ventilation. The latter was supported by the inability of the newborn to tolerate metabolic-ventilatory stimulation following administration of the metabolic uncoupler, 2,4-dinitrophenol (2,4-DNP). At 1 week of age, the cost of breathing was reduced, which coincided with the expression of a significant ventilatory response to hypoxia, a more energetically efficient respiratory system, and tolerance to 2,4-DNP. These data suggest this species of marsupial is born with major respiratory insufficiency, and that their pronounced dependence on the skin for metabolic gas exchange is of critical importance for survival.