Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos

Niacin, also known as vitamin B3, has a pivotal role in energy metabolism, cellular signaling cascades regulating gene expression, and apoptosis. However, the effect of Niacin on porcine early embryo developmental competence remains to be elucidated. The present study aimed to assess the effects of...

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Bibliographic Details
Published in:Theriogenology 2021-07, Vol.169, p.36-46
Main Authors: Almubarak, Areeg M., Kim, Eunji, Yu, Il-Jeoung, Jeon, Yubyeol
Format: Article
Language:English
Subjects:
Apoptosis
Glutathione
In vitro maturation
Oocytes
Oxidative stress
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Summary:Niacin, also known as vitamin B3, has a pivotal role in energy metabolism, cellular signaling cascades regulating gene expression, and apoptosis. However, the effect of Niacin on porcine early embryo developmental competence remains to be elucidated. The present study aimed to assess the effects of Niacin treatment during in vitro maturation (IVM) on the nuclear maturation of porcine oocytes and subsequent development of in vitro embryos. In addition, the expression profiles of selected genes related to lipid metabolism, oxidative stress, and apoptosis were assessed. The IVM medium was supplemented with different concentrations of Niacin (0, 300, 600, and 900 μM). The results showed that a high concentration of Niacin (900 μM) significantly decreased cumulus expansion compared to the other groups (p 
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2021.04.005