An EAACI Task Force report on allergy to beta‐lactams in children: Clinical entities and diagnostic procedures

Beta‐lactam (BL) allergy suspicion is common in children and constitutes a major public health problem, with an impact on patient's health and on medical costs. However, it has been found that most of these reactions are not confirmed by a complete allergic workup. The diagnostic value of the c...

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Bibliographic Details
Published in:Pediatric allergy and immunology 2021-10, Vol.32 (7), p.1426-1436
Main Authors: Blanca‐Lopez, Natalia, Atanaskovic‐Markovic, Marina, Gomes, Eva R., Kidon, Mona, Kuyucu, Semanur, Mori, Francesca, Soyer, Ozge, Caubet, Jean‐Christoph, Riggioni, Carmen
Format: Article
Language:English
Subjects:
Allergies
beta‐lactam allergy
Children
immediate reactions
Medical diagnosis
non‐immediate reactions
Public health
Skin tests
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Summary:Beta‐lactam (BL) allergy suspicion is common in children and constitutes a major public health problem, with an impact on patient's health and on medical costs. However, it has been found that most of these reactions are not confirmed by a complete allergic workup. The diagnostic value of the currently available allergy tests has been investigated intensively recently by different groups throughout the world. This has led to major changes in the management of children with a suspected BL allergy. Particularly, it is now well accepted that skin tests can be skipped before the drug provocation test in children with a benign non‐immediate reaction to BL. However, there is still a debate on the optimal allergic workup to perform in children with a benign immediate reaction. In addition, management of children with severe cutaneous adverse drug reactions remains difficult. In this review, based on a selection of the most relevant studies found in the literature, we will review and discuss the diagnosis of different forms of BL allergy in children.
ISSN:0905-6157
1399-3038
DOI:10.1111/pai.13529