Visible-Light-Induced α-Amino C-H Bond Arylation Enabled by Electron Donor-Acceptor Complexes

Enabled by electron donor-acceptor complexes, a novel visible-light-induced α-amino C-H bond arylation protocol, without a photoredox catalyst, has been disclosed. The protocol does not require any transition metal, oxidant, or exclusion of oxygen or moisture. A direct irradiation of the mixture of...

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Bibliographic Details
Published in:Organic letters 2021-05, Vol.23 (10), p.3913-3918
Main Authors: Xu, Chang, Shen, Fang-Qi, Feng, Gaofeng, Jin, Jian
Format: Article
Language:English
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Summary:Enabled by electron donor-acceptor complexes, a novel visible-light-induced α-amino C-H bond arylation protocol, without a photoredox catalyst, has been disclosed. The protocol does not require any transition metal, oxidant, or exclusion of oxygen or moisture. A direct irradiation of the mixture of tertiary amines and benzonitriles with visible light in , -diethylethanamide in the presence of Cs CO afforded α-arylated amines in good to excellent yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c00984