Impact of serum calcium levels on total body bone mineral density: A mendelian randomization study in five age strata

Mendelian randomization (MR) studies have reported the causal association between serum calcium levels and bone mineral density (BMD). The results showed that genetically increased serum calcium levels in individuals with normal calcium levels did not increase BMD and could even reduce BMD. However,...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2021-05, Vol.40 (5), p.2726-2733
Main Authors: Sun, Jing-yi, Zhang, Haihua, Zhang, Yan, Wang, Longcai, Sun, Bao-liang, Gao, Feng, Liu, Guiyou
Format: Article
Language:English
Subjects:
Bone mineral density
Genome-wide association studies
Mendelian randomization
Serum calcium
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Summary:Mendelian randomization (MR) studies have reported the causal association between serum calcium levels and bone mineral density (BMD). The results showed that genetically increased serum calcium levels in individuals with normal calcium levels did not increase BMD and could even reduce BMD. However, whether there are differences in the association between serum calcium and BMD in different age strata remains unclear. We selected eight serum calcium genetic variants with genome-wide significance (P 
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2021.03.012