Conventional Ultrasound Combined With Contrast‐Enhanced Ultrasound in Differential Diagnosis of Gallbladder Cholesterol and Adenomatous Polyps (1–2 cm)

• Published in: Journal of ultrasound in medicine 2022-03, Vol.41 (3), p.617-626
• Main Authors: Wang, Xue, Zhu, Jia‐an, Liu, Yue‐jie, Liu, Yi‐qun, Che, Dong‐dong, Niu, Si‐hua, Gao, Shuang, Chen, Ding‐bao
• Format: Article
• Language: English
• Subjects: adenomatous polyp; Adenomatous Polyps - diagnostic imaging; Cholesterol; cholesterol polyp; Contrast Media; contrast‐enhanced ultrasound (CEUS); conventional ultrasound (CUS); Diagnosis, Differential; Gallbladder Neoplasms - diagnosis; gallbladder polyp; Humans; Polyps - diagnostic imaging; Ultrasonography
• ISSN: 0278-4297; 1550-9613
• DOI: 10.1002/jum.15740

Objectives This study aimed to determine ultrasonic image characteristics that enable differentiation between cholesterol and adenomatous polyps and to assess the diagnostic efficacy of combining conventional ultrasound (CUS) with contrast‐enhanced ultrasound (CEUS). Methods Eighty‐nine patients with gallbladder polyps of 1–2 cm in diameter were enrolled and examined by CUS and CEUS before cholecystectomy. The appearances on CUS and CEUS were recorded and analyzed. The receiver operating characteristic (ROC) curve was used to calculate the optimal size threshold for distinguishing cholesterol from adenomatous polyps. A logistic regression analysis was performed to identify diagnostic variables. ROC analysis was performed to evaluate the diagnostic efficacy of the size, the independent variables, and the combined factors. Results There were differences in size, number, vascularity on CUS and intralesional vascular shape, wash‐out, and area under the curve on CEUS between the two groups (P