Can first trimester pregnancy-associated plasma protein-A predict the surfactant needs of preterm neonates?

BACKGROUND: Low values of pregnancy associated plasma protein A (PAPP-A), have been shown to be associated with some poor gestational outcomes, especially those related to placental deficiency such as pre-eclampsia and fetal growth restriction as well as preterm labor. The aim of this study was to c...

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Bibliographic Details
Published in:Journal of neonatal-perinatal medicine 2022-01, Vol.15 (1), p.123-128
Main Authors: Yakistiran, B., Karsli, M.F., Canpolat, F.E.
Format: Article
Language:English
Subjects:
Biomarkers
Female
Humans
Infant, Newborn
Infant, Premature
Placenta
Pregnancy
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A
Surface-Active Agents
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Summary:BACKGROUND: Low values of pregnancy associated plasma protein A (PAPP-A), have been shown to be associated with some poor gestational outcomes, especially those related to placental deficiency such as pre-eclampsia and fetal growth restriction as well as preterm labor. The aim of this study was to compare first trimester PAPP-A MoM values with the surfactant needs of newborns of pregnant women who had a preterm delivery. METHODS: This study included 216 pregnant women who had a preterm delivery, who were found to be in the low-risk group based on their aneuploidy screening. The women were separated into two groups based on the surfactant receipts of their newborns. A record was made of the obstetric history, birth characteristics of the preterm infants, and whether or not there was a need for surfactant. RESULTS: A comparison of the PAPP-A values of the two groups revealed that the group that received surfactant had statistically significantly lower PAPP-A values (t(–3.97) = 0.203, p 
ISSN:1934-5798
1878-4429
DOI:10.3233/NPM-200560