Gold nanoparticles-based assays for biodetection in urine

Urine is a biofluid easy to collect through a non-invasive technique that allows collecting a large volume of sample. The use of urine for disease diagnosis is not yet well explored. However, it has gained attention over the last three years. It has been applied in the diagnosis of several illnesses...

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Bibliographic Details
Published in:Talanta (Oxford) 2021-08, Vol.230, p.122345-122345, Article 122345
Main Authors: António, Maria, Vitorino, Rui, Daniel-da-Silva, Ana L.
Format: Article
Language:English
Subjects:
Biodetection
Biological Assay
Biosensing Techniques
Gold
Gold nanoparticles
Male
Metal Nanoparticles
Protein
Surface modification
Urine samples
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Summary:Urine is a biofluid easy to collect through a non-invasive technique that allows collecting a large volume of sample. The use of urine for disease diagnosis is not yet well explored. However, it has gained attention over the last three years. It has been applied in the diagnosis of several illnesses such as kidney disease, bladder cancer, prostate cancer and cardiovascular diseases. In the last decade, gold nanoparticles (Au NPs) have attracted attention in biosensors' development for the diagnosis of diseases due to their electrical and optical properties, ability to conjugate with biomolecules, high sensitivity, and selectivity. Therefore, this article aims to present a comprehensive view of state of the art on the advances made in the quantification of analytes in urinary samples using AuNPs based assays, with a focus on protein analysis. The type of diagnosis methods, the Au NPs synthesis approaches and the strategies for surface modification aiming at selectivity towards the different targets are highlighted. [Display omitted] •Surface modification and bioconjugation of Au nanoparticles for sensing.•Different types of assays for biodetection in urine are discussed.•Recent developments of Au nanoparticle-based methods for urine analysis are reviewed.
ISSN:0039-9140
1873-3573
DOI:10.1016/j.talanta.2021.122345