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Immediate local anesthetic reactions and diagnostic test results in pediatric patients
Adverse reactions to local anesthetics are relatively common, but proven IgE-mediated allergy is extremely rare. We aimed to determine the frequency of local anesthetic allergy in pediatric patients. The medical records of 73 patients who presented to our clinic with a history of suspected allergic...
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| Published in: | Allergologia et immunopathologia 2021-01, Vol.49 (3), p.108-114 |
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| Main Authors: | , , , , , , |
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| container_end_page | 114 |
| container_issue | 3 |
| container_start_page | 108 |
| container_title | Allergologia et immunopathologia |
| container_volume | 49 |
| creator | Selmanoglu, Ahmet Güvenir, Hakan Celik, Ilknur Kulhas Karaatmaca, Betul Toyran, Müge Civelek, Ersoy Misirlioglu, Emine Dibek |
| description | Adverse reactions to local anesthetics are relatively common, but proven IgE-mediated allergy is extremely rare. We aimed to determine the frequency of local anesthetic allergy in pediatric patients.
The medical records of 73 patients who presented to our clinic with a history of suspected allergic reaction to local anesthetics and underwent diagnostic testing between 2012 and 2020 were retrospectively analyzed. Diagnoses were based on case histories, skin tests, and subcutaneous challenge tests.
A total of 75 test series were carried out on the 73 patients (43 boys; median [IQR] age 9.25 [7.26-14.25] years, range 3-17.8 years). The most commonly tested drugs were lidocaine (n = 38; 50.6%) and prilocaine (n = 15; 20%). Local anesthetic allergy was confirmed in one (1.3%) of the 73 patients by positive subcutaneous challenge test with mepivacaine.
There are limited data in the current literature regarding local anesthetic allergies and diagnosis test results in pediatric patients. Proven local anesthetic allergy is less common than expected by society and physicians, and therefore diagnostic tests are needed for patients with no contra-indications such as severe or life-threatening reactions. |
| doi_str_mv | 10.15586/aei.v49i3.87 |
| format | article |
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The medical records of 73 patients who presented to our clinic with a history of suspected allergic reaction to local anesthetics and underwent diagnostic testing between 2012 and 2020 were retrospectively analyzed. Diagnoses were based on case histories, skin tests, and subcutaneous challenge tests.
A total of 75 test series were carried out on the 73 patients (43 boys; median [IQR] age 9.25 [7.26-14.25] years, range 3-17.8 years). The most commonly tested drugs were lidocaine (n = 38; 50.6%) and prilocaine (n = 15; 20%). Local anesthetic allergy was confirmed in one (1.3%) of the 73 patients by positive subcutaneous challenge test with mepivacaine.
There are limited data in the current literature regarding local anesthetic allergies and diagnosis test results in pediatric patients. Proven local anesthetic allergy is less common than expected by society and physicians, and therefore diagnostic tests are needed for patients with no contra-indications such as severe or life-threatening reactions.</description><identifier>ISSN: 0301-0546</identifier><identifier>EISSN: 1578-1267</identifier><identifier>EISSN: 0301-0546</identifier><identifier>DOI: 10.15586/aei.v49i3.87</identifier><identifier>PMID: 33938195</identifier><language>eng</language><publisher>Singapore: Codon Publications</publisher><subject>Adolescent ; Anesthetics, Local - adverse effects ; Anesthetics, Local - immunology ; Asthma ; Child ; Child, Preschool ; Circumcision ; Diagnostic tests ; Drug Hypersensitivity - diagnosis ; Drug Hypersensitivity - etiology ; Erythema ; Female ; Food allergies ; Humans ; Hypersensitivity, Immediate - diagnosis ; Hypersensitivity, Immediate - etiology ; Immunoglobulin E ; Intradermal Tests ; Lidocaine - adverse effects ; Lidocaine - immunology ; Local anesthesia ; Male ; Mepivacaine - adverse effects ; Mepivacaine - immunology ; Nonsteroidal anti-inflammatory drugs ; Patients ; Pediatrics ; Prilocaine - adverse effects ; Prilocaine - immunology ; Retrospective Studies ; Skin Tests ; Urticaria</subject><ispartof>Allergologia et immunopathologia, 2021-01, Vol.49 (3), p.108-114</ispartof><rights>2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-3f49f7049e7f4abe9ddf3f06866563c39e11b167b6ae8260a0f4465c823e3d503</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2724319579/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2724319579?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,25731,27901,27902,36989,36990,44566,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33938195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Selmanoglu, Ahmet</creatorcontrib><creatorcontrib>Güvenir, Hakan</creatorcontrib><creatorcontrib>Celik, Ilknur Kulhas</creatorcontrib><creatorcontrib>Karaatmaca, Betul</creatorcontrib><creatorcontrib>Toyran, Müge</creatorcontrib><creatorcontrib>Civelek, Ersoy</creatorcontrib><creatorcontrib>Misirlioglu, Emine Dibek</creatorcontrib><title>Immediate local anesthetic reactions and diagnostic test results in pediatric patients</title><title>Allergologia et immunopathologia</title><addtitle>Allergol Immunopathol (Madr)</addtitle><description>Adverse reactions to local anesthetics are relatively common, but proven IgE-mediated allergy is extremely rare. We aimed to determine the frequency of local anesthetic allergy in pediatric patients.
The medical records of 73 patients who presented to our clinic with a history of suspected allergic reaction to local anesthetics and underwent diagnostic testing between 2012 and 2020 were retrospectively analyzed. Diagnoses were based on case histories, skin tests, and subcutaneous challenge tests.
A total of 75 test series were carried out on the 73 patients (43 boys; median [IQR] age 9.25 [7.26-14.25] years, range 3-17.8 years). The most commonly tested drugs were lidocaine (n = 38; 50.6%) and prilocaine (n = 15; 20%). Local anesthetic allergy was confirmed in one (1.3%) of the 73 patients by positive subcutaneous challenge test with mepivacaine.
There are limited data in the current literature regarding local anesthetic allergies and diagnosis test results in pediatric patients. Proven local anesthetic allergy is less common than expected by society and physicians, and therefore diagnostic tests are needed for patients with no contra-indications such as severe or life-threatening reactions.</description><subject>Adolescent</subject><subject>Anesthetics, Local - adverse effects</subject><subject>Anesthetics, Local - immunology</subject><subject>Asthma</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Circumcision</subject><subject>Diagnostic tests</subject><subject>Drug Hypersensitivity - diagnosis</subject><subject>Drug Hypersensitivity - etiology</subject><subject>Erythema</subject><subject>Female</subject><subject>Food allergies</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - diagnosis</subject><subject>Hypersensitivity, Immediate - etiology</subject><subject>Immunoglobulin E</subject><subject>Intradermal Tests</subject><subject>Lidocaine - adverse effects</subject><subject>Lidocaine - immunology</subject><subject>Local anesthesia</subject><subject>Male</subject><subject>Mepivacaine - adverse effects</subject><subject>Mepivacaine - immunology</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Prilocaine - adverse effects</subject><subject>Prilocaine - immunology</subject><subject>Retrospective Studies</subject><subject>Skin Tests</subject><subject>Urticaria</subject><issn>0301-0546</issn><issn>1578-1267</issn><issn>0301-0546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkEtLAzEURoMotlaXbmXAjZupSW4ek6UUH4WCG3UbMjMZTZlHTTKC_970oQtXF-53-Lj3IHRJ8JxwXohbY938iykH80IeoSnhssgJFfIYTTFgkmPOxASdhbDGmGIq4BRNABQURPEpelt2na2diTZrh8q0meltiB82uirz1lTRDX1IyzpL0Hs_hG0QE5LSMLYxZK7PNrsGn5KNic72MZyjk8a0wV4c5gy9Pty_LJ7y1fPjcnG3yiugJObQMNVIzJSVDTOlVXXdQINFIQQXUIGyhJREyFIYW1CBDW4YE7wqKFioOYYZutn3bvzwOaazdOdCZds2vTGMQVNOCVMKmEro9T90PYy-T9dpKimDpENuqXxPVX4IwdtGb7zrjP_WBOudcJ2E651wXcjEXx1axzKJ_KN_DcMPBmN8mw</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Selmanoglu, Ahmet</creator><creator>Güvenir, Hakan</creator><creator>Celik, Ilknur Kulhas</creator><creator>Karaatmaca, Betul</creator><creator>Toyran, Müge</creator><creator>Civelek, Ersoy</creator><creator>Misirlioglu, Emine Dibek</creator><general>Codon Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210101</creationdate><title>Immediate local anesthetic reactions and diagnostic test results in pediatric patients</title><author>Selmanoglu, Ahmet ; 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We aimed to determine the frequency of local anesthetic allergy in pediatric patients.
The medical records of 73 patients who presented to our clinic with a history of suspected allergic reaction to local anesthetics and underwent diagnostic testing between 2012 and 2020 were retrospectively analyzed. Diagnoses were based on case histories, skin tests, and subcutaneous challenge tests.
A total of 75 test series were carried out on the 73 patients (43 boys; median [IQR] age 9.25 [7.26-14.25] years, range 3-17.8 years). The most commonly tested drugs were lidocaine (n = 38; 50.6%) and prilocaine (n = 15; 20%). Local anesthetic allergy was confirmed in one (1.3%) of the 73 patients by positive subcutaneous challenge test with mepivacaine.
There are limited data in the current literature regarding local anesthetic allergies and diagnosis test results in pediatric patients. Proven local anesthetic allergy is less common than expected by society and physicians, and therefore diagnostic tests are needed for patients with no contra-indications such as severe or life-threatening reactions.</abstract><cop>Singapore</cop><pub>Codon Publications</pub><pmid>33938195</pmid><doi>10.15586/aei.v49i3.87</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Anesthetics, Local - adverse effects Anesthetics, Local - immunology Asthma Child Child, Preschool Circumcision Diagnostic tests Drug Hypersensitivity - diagnosis Drug Hypersensitivity - etiology Erythema Female Food allergies Humans Hypersensitivity, Immediate - diagnosis Hypersensitivity, Immediate - etiology Immunoglobulin E Intradermal Tests Lidocaine - adverse effects Lidocaine - immunology Local anesthesia Male Mepivacaine - adverse effects Mepivacaine - immunology Nonsteroidal anti-inflammatory drugs Patients Pediatrics Prilocaine - adverse effects Prilocaine - immunology Retrospective Studies Skin Tests Urticaria |
| title | Immediate local anesthetic reactions and diagnostic test results in pediatric patients |
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