An automated radiosynthesis of (S)-[18F]28 for PET imaging of Alzheimer's disease

• Published in: Applied radiation and isotopes 2021-08, Vol.174, p.109740-109740, Article 109740
• Main Authors: Xie, Ji-Kui, Zhu, Xing-Xing, Wang, Kai-Xuan, Wang, Shi-Cun, Xie, Qiang
• Format: Article
• Language: English
• Subjects: (S)-[18F]28; Alzheimer Disease - diagnostic imaging; Alzheimer's disease; Automated radiosynthesis; Automation; Aβ tracers; Fluorine Radioisotopes - chemistry; Humans; PET-CT; Positron-Emission Tomography - methods; Radiochemistry - methods; Radiopharmaceuticals - chemical synthesis
• ISSN: 0969-8043; 1872-9800
• DOI: 10.1016/j.apradiso.2021.109740

18F-labeled 2-arylbenzoxazole derivative (S)-[18F]28 is potent and selective radiopharmaceutical Aβ tracers for Alzheimer's disease positron-emission tomography (PET). Our study aimed to enable facile preparation of (S)-[18F]28 in commercially available PET tracer production facilities to promote the widespread application and clinical translation. Here, we successfully demonstrated an automated radiosynthesis of (S)-[18F]28 with high radiochemical yield and radiochemical purity by the AllinOne radiosynthesis module. The method developed here can facilitate extensive use of (S)-[18F]28 in large-scale clinical trials. •A concise and facile fully automatic synthesis of (S)-[18F]28 was proposed.•A commercially available AllinOne radiosynthesis module was used for production.•The non-decay corrected radiochemical yield were 36 ± 1.9% with >95% radiochemical purity in less than 60 min.•Facilitating the widespread use of (S)-[18F]28 in large-scale clinical trials.