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Role of dyslipidemia in ischemic stroke patients treated in the telestroke network
The relationship between the telestroke technology and clinical risk factors in a dysplipidemic ischemic stroke population and neurologic outcomes is not fully understood. This issue was investigated in this study. We analyzed retrospective data collected from a regional stroke registry to identify...
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| Published in: | Advances in medical sciences 2021-09, Vol.66 (2), p.254-261 |
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| cites | cdi_FETCH-LOGICAL-c359t-d6683bec6eee7068875911d3076c16e24293f6e1963b10190f8bee3f5343847a3 |
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| container_title | Advances in medical sciences |
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| creator | Brechtel, Leanne Poupore, Nicolas Monroe, Margaret Knisely, Krista Sanders, Carolyn Edrissi, Camron Rathfoot, Chase Nathaniel, Thomas I. |
| description | The relationship between the telestroke technology and clinical risk factors in a dysplipidemic ischemic stroke population and neurologic outcomes is not fully understood. This issue was investigated in this study.
We analyzed retrospective data collected from a regional stroke registry to identify demographic and clinical risk factors in patients with improving (NIHSS ≤ 7) or worsening (NIHSS > 7) neurologic outcome in dyslipidemic ischemic stroke population. We used logistic multivariate models to identify independent predictors of improving or worsening outcome based on dyslipidemia disease status in ischemic stroke patients.
In the adjusted analysis for dyslipidemic ischemic stroke population, cholesterol reducer use (odd ratio; [OR] = 0.393, 95% confidence interval [CI], 0.176–0.879, P = 0.023) and direct admission (OR = 0.435, 95% CI, 0.199–0.953, P = 0.037) were more likely to be associated with neurologic improvement and no clinical or demographic factors were associated with poor neurologic outcome in dyslipidemic ischemic stroke patients treated in the telestroke network.
For the ischemic stroke population without dyslipidemia, increasing age (OR = 1.070, 95% CI, 1.031–1.109, P |
| doi_str_mv | 10.1016/j.advms.2021.04.003 |
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We analyzed retrospective data collected from a regional stroke registry to identify demographic and clinical risk factors in patients with improving (NIHSS ≤ 7) or worsening (NIHSS > 7) neurologic outcome in dyslipidemic ischemic stroke population. We used logistic multivariate models to identify independent predictors of improving or worsening outcome based on dyslipidemia disease status in ischemic stroke patients.
In the adjusted analysis for dyslipidemic ischemic stroke population, cholesterol reducer use (odd ratio; [OR] = 0.393, 95% confidence interval [CI], 0.176–0.879, P = 0.023) and direct admission (OR = 0.435, 95% CI, 0.199–0.953, P = 0.037) were more likely to be associated with neurologic improvement and no clinical or demographic factors were associated with poor neurologic outcome in dyslipidemic ischemic stroke patients treated in the telestroke network.
For the ischemic stroke population without dyslipidemia, increasing age (OR = 1.070, 95% CI, 1.031–1.109, P < 0.001), coronary artery disease (OR = 3.633, 95% CI, 1.307–10.099, P = 0.013), history of drug or alcohol abuse (OR = 6.548, 95% CI, 1.106–38.777, P = 0.038), and improvement in ambulatory outcome (OR = 2.880, 95% CI, 1.183–7.010, P = 0.020) were associated with worsening neurological functions, while being Caucasian (OR = 0.294, 95% CI, 0.098–0.882, P = 0.029) was associated with improving neurologic functions.
Demographic and clinical risk factors among the dysplipidemic ischemic stroke population in the telestroke network were not associated with worsening neurologic functions.</description><identifier>ISSN: 1896-1126</identifier><identifier>EISSN: 1898-4002</identifier><identifier>DOI: 10.1016/j.advms.2021.04.003</identifier><identifier>PMID: 33940526</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Brain Ischemia - complications ; Dyslipidemia ; Dyslipidemias - complications ; Dyslipidemias - epidemiology ; Humans ; Ischemic Stroke ; Neurologic outcome ; NIHSS score ; Retrospective Studies ; Risk Factors ; Stroke ; Stroke - complications ; Telestroke ; Time Factors ; Treatment Outcome</subject><ispartof>Advances in medical sciences, 2021-09, Vol.66 (2), p.254-261</ispartof><rights>2021 Medical University of Bialystok</rights><rights>Copyright © 2021 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-d6683bec6eee7068875911d3076c16e24293f6e1963b10190f8bee3f5343847a3</citedby><cites>FETCH-LOGICAL-c359t-d6683bec6eee7068875911d3076c16e24293f6e1963b10190f8bee3f5343847a3</cites><orcidid>0000-0001-7488-859X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33940526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brechtel, Leanne</creatorcontrib><creatorcontrib>Poupore, Nicolas</creatorcontrib><creatorcontrib>Monroe, Margaret</creatorcontrib><creatorcontrib>Knisely, Krista</creatorcontrib><creatorcontrib>Sanders, Carolyn</creatorcontrib><creatorcontrib>Edrissi, Camron</creatorcontrib><creatorcontrib>Rathfoot, Chase</creatorcontrib><creatorcontrib>Nathaniel, Thomas I.</creatorcontrib><title>Role of dyslipidemia in ischemic stroke patients treated in the telestroke network</title><title>Advances in medical sciences</title><addtitle>Adv Med Sci</addtitle><description>The relationship between the telestroke technology and clinical risk factors in a dysplipidemic ischemic stroke population and neurologic outcomes is not fully understood. This issue was investigated in this study.
We analyzed retrospective data collected from a regional stroke registry to identify demographic and clinical risk factors in patients with improving (NIHSS ≤ 7) or worsening (NIHSS > 7) neurologic outcome in dyslipidemic ischemic stroke population. We used logistic multivariate models to identify independent predictors of improving or worsening outcome based on dyslipidemia disease status in ischemic stroke patients.
In the adjusted analysis for dyslipidemic ischemic stroke population, cholesterol reducer use (odd ratio; [OR] = 0.393, 95% confidence interval [CI], 0.176–0.879, P = 0.023) and direct admission (OR = 0.435, 95% CI, 0.199–0.953, P = 0.037) were more likely to be associated with neurologic improvement and no clinical or demographic factors were associated with poor neurologic outcome in dyslipidemic ischemic stroke patients treated in the telestroke network.
For the ischemic stroke population without dyslipidemia, increasing age (OR = 1.070, 95% CI, 1.031–1.109, P < 0.001), coronary artery disease (OR = 3.633, 95% CI, 1.307–10.099, P = 0.013), history of drug or alcohol abuse (OR = 6.548, 95% CI, 1.106–38.777, P = 0.038), and improvement in ambulatory outcome (OR = 2.880, 95% CI, 1.183–7.010, P = 0.020) were associated with worsening neurological functions, while being Caucasian (OR = 0.294, 95% CI, 0.098–0.882, P = 0.029) was associated with improving neurologic functions.
Demographic and clinical risk factors among the dysplipidemic ischemic stroke population in the telestroke network were not associated with worsening neurologic functions.</description><subject>Brain Ischemia - complications</subject><subject>Dyslipidemia</subject><subject>Dyslipidemias - complications</subject><subject>Dyslipidemias - epidemiology</subject><subject>Humans</subject><subject>Ischemic Stroke</subject><subject>Neurologic outcome</subject><subject>NIHSS score</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Stroke - complications</subject><subject>Telestroke</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1896-1126</issn><issn>1898-4002</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMlOwzAQhi0EoqXwBEgoRy4JYztxkgMHhNikSkgVnK3EnqhusxTbLerb4y5w5DRz-P5ZPkKuKSQUqLhbJJXedC5hwGgCaQLAT8iYFmURpwDsdN-LmFImRuTCuQWAYALgnIw4L1PImBiT2WxoMRqaSG9da1ZGY2eqyPSRcWoeehU5b4clRqvKG-y9i7zFyqPeMX6OkccWj0iP_nuwy0ty1lStw6tjnZDP56ePx9d4-v7y9vgwjRXPSh9rIQpeoxKImIMoijwrKdUccqGoQJaykjcCaSl4Hf4toSlqRN5kPOVFmld8Qm4Pc1d2-FqHI2QXjsa2rXoc1k6yjDFa5CXNA8oPqLKDcxYbubKmq-xWUpA7mXIh9zLlTqaEVAaZIXVzXLCuO9R_mV97Abg_ABje3Bi00qkgSaE2FpWXejD_LvgBa1-GSw</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Brechtel, Leanne</creator><creator>Poupore, Nicolas</creator><creator>Monroe, Margaret</creator><creator>Knisely, Krista</creator><creator>Sanders, Carolyn</creator><creator>Edrissi, Camron</creator><creator>Rathfoot, Chase</creator><creator>Nathaniel, Thomas I.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7488-859X</orcidid></search><sort><creationdate>202109</creationdate><title>Role of dyslipidemia in ischemic stroke patients treated in the telestroke network</title><author>Brechtel, Leanne ; Poupore, Nicolas ; Monroe, Margaret ; Knisely, Krista ; Sanders, Carolyn ; Edrissi, Camron ; Rathfoot, Chase ; Nathaniel, Thomas I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-d6683bec6eee7068875911d3076c16e24293f6e1963b10190f8bee3f5343847a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Brain Ischemia - complications</topic><topic>Dyslipidemia</topic><topic>Dyslipidemias - complications</topic><topic>Dyslipidemias - epidemiology</topic><topic>Humans</topic><topic>Ischemic Stroke</topic><topic>Neurologic outcome</topic><topic>NIHSS score</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Stroke - complications</topic><topic>Telestroke</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brechtel, Leanne</creatorcontrib><creatorcontrib>Poupore, Nicolas</creatorcontrib><creatorcontrib>Monroe, Margaret</creatorcontrib><creatorcontrib>Knisely, Krista</creatorcontrib><creatorcontrib>Sanders, Carolyn</creatorcontrib><creatorcontrib>Edrissi, Camron</creatorcontrib><creatorcontrib>Rathfoot, Chase</creatorcontrib><creatorcontrib>Nathaniel, Thomas I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advances in medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brechtel, Leanne</au><au>Poupore, Nicolas</au><au>Monroe, Margaret</au><au>Knisely, Krista</au><au>Sanders, Carolyn</au><au>Edrissi, Camron</au><au>Rathfoot, Chase</au><au>Nathaniel, Thomas I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of dyslipidemia in ischemic stroke patients treated in the telestroke network</atitle><jtitle>Advances in medical sciences</jtitle><addtitle>Adv Med Sci</addtitle><date>2021-09</date><risdate>2021</risdate><volume>66</volume><issue>2</issue><spage>254</spage><epage>261</epage><pages>254-261</pages><issn>1896-1126</issn><eissn>1898-4002</eissn><abstract>The relationship between the telestroke technology and clinical risk factors in a dysplipidemic ischemic stroke population and neurologic outcomes is not fully understood. This issue was investigated in this study.
We analyzed retrospective data collected from a regional stroke registry to identify demographic and clinical risk factors in patients with improving (NIHSS ≤ 7) or worsening (NIHSS > 7) neurologic outcome in dyslipidemic ischemic stroke population. We used logistic multivariate models to identify independent predictors of improving or worsening outcome based on dyslipidemia disease status in ischemic stroke patients.
In the adjusted analysis for dyslipidemic ischemic stroke population, cholesterol reducer use (odd ratio; [OR] = 0.393, 95% confidence interval [CI], 0.176–0.879, P = 0.023) and direct admission (OR = 0.435, 95% CI, 0.199–0.953, P = 0.037) were more likely to be associated with neurologic improvement and no clinical or demographic factors were associated with poor neurologic outcome in dyslipidemic ischemic stroke patients treated in the telestroke network.
For the ischemic stroke population without dyslipidemia, increasing age (OR = 1.070, 95% CI, 1.031–1.109, P < 0.001), coronary artery disease (OR = 3.633, 95% CI, 1.307–10.099, P = 0.013), history of drug or alcohol abuse (OR = 6.548, 95% CI, 1.106–38.777, P = 0.038), and improvement in ambulatory outcome (OR = 2.880, 95% CI, 1.183–7.010, P = 0.020) were associated with worsening neurological functions, while being Caucasian (OR = 0.294, 95% CI, 0.098–0.882, P = 0.029) was associated with improving neurologic functions.
Demographic and clinical risk factors among the dysplipidemic ischemic stroke population in the telestroke network were not associated with worsening neurologic functions.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33940526</pmid><doi>10.1016/j.advms.2021.04.003</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7488-859X</orcidid></addata></record> |
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| language | eng |
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| source | Elsevier |
| subjects | Brain Ischemia - complications Dyslipidemia Dyslipidemias - complications Dyslipidemias - epidemiology Humans Ischemic Stroke Neurologic outcome NIHSS score Retrospective Studies Risk Factors Stroke Stroke - complications Telestroke Time Factors Treatment Outcome |
| title | Role of dyslipidemia in ischemic stroke patients treated in the telestroke network |
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