Application of photodynamic therapy in immune-related diseases

•Mechanisms and biological effects of photodynamic therapy (PDT).•Immunomodulatory characteristics of PDT.•Principles and clinical application of PDT in the treatment of immune-related diseases. Photodynamic therapy (PDT) is a therapeutic modality that utilizes photodamage caused by photosensitizers...

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Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2021-06, Vol.34, p.102318-102318, Article 102318
Main Authors: Yang, Dan, Lei, Shangxue, Pan, Keran, Chen, Ting, Lin, Jiao, Ni, Guangcheng, Liu, Jiaxin, Zeng, Xin, Chen, Qianming, Dan, Hongxia
Format: Article
Language:English
Subjects:
Immune-Related diseases
Immunomodulation
Photodynamic therapy
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Summary:•Mechanisms and biological effects of photodynamic therapy (PDT).•Immunomodulatory characteristics of PDT.•Principles and clinical application of PDT in the treatment of immune-related diseases. Photodynamic therapy (PDT) is a therapeutic modality that utilizes photodamage caused by photosensitizers and oxygen after exposure to a specific wavelength of light. Owing to its low toxicity, high selectivity, and minimally invasive properties, PDT has been widely applied to treat various malignant tumors, premalignant lesions, and infectious diseases. Moreover, there is growing evidence of its immunomodulatory effects and potential for the treatment of immune-related diseases. This review mainly focuses on the effect of PDT on immunity and its application in immune-related diseases.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2021.102318