Zinc oxide spiky nanoparticles: A promising nanomaterial for killing tumor cells

Zinc oxide (ZnO) nanostructures have been widely studied in biomedical fields due to their special properties. In recent years, ZnO spherical nanoparticles (SNPs) with nano-size as an anti-tumor agent have been widely concerned. While the effects of the non-spherical shaped ZnO nanoparticles on tumo...

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Bibliographic Details
Published in:Materials Science & Engineering C 2021-05, Vol.124, p.112071-112071, Article 112071
Main Authors: Dang, Zechun, Sun, Jizheng, Fan, Jiaqi, Li, Jinqi, Li, Xinlei, Chen, Tongsheng
Format: Article
Language:English
Subjects:
Anti-tumor
Anticancer properties
Biocompatibility
Cell Count
Cell death
Cytotoxicity
Long term cytotoxicity
Materials science
Nanomaterials
Nanomedicine
Nanoparticles
Nanotechnology
Spheroids
Toxicity
Tumor cells
Zinc oxide
Zinc Oxide - pharmacology
Zinc oxides
ZnO spiky nanoparticles
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Summary:Zinc oxide (ZnO) nanostructures have been widely studied in biomedical fields due to their special properties. In recent years, ZnO spherical nanoparticles (SNPs) with nano-size as an anti-tumor agent have been widely concerned. While the effects of the non-spherical shaped ZnO nanoparticles on tumor cell death have been rarely reported. Here, we prepared ZnO spiky nanoparticles (SPNPs) as the research subject. We found that the SPNPs showed superiority in killing tumor cells. To be specific, SPNPs presented a long-term cytotoxicity effect on killing tumor cells, as plenty of SPNPs retained on the cell plasma membrane's exterior and still showed toxicity effect on tumor cells after co-incubation multiple times. Moreover, compared to SNPs, it was encouraging that SPNPs still showed stronger cytotoxicity in both simulated circulatory systems of tumor cells and 3D tumor cell spheroids. The stronger toxicity against tumor cells suggested that ZnO SPNPs have more advantages on killing tumor cells as a promising nanomedicine. ZnO spiky nanoparticles present a long-term efficiency on killing tumor cells. [Display omitted] •ZnO spiky nanoparticles exhibit wide toxicity on different tumor cell lines while no toxicity on normal cells.•ZnO spiky nanoparticles present superiority of long-term cytotoxicity against tumor cells.•ZnO spiky nanoparticles are a promising nanomedicine for killing tumor cells.
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2021.112071