Development and characterization of gel-in-water nanoemulsion as a novel drug delivery system

The effective delivery of anti-cancer drugs with minimal side effects and better therapeutic efficacy has remained an active area of research for many decades. Organogels have gained attention in recent years as potential drug delivery systems due to their high bioavailability, no first-pass metabol...

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Bibliographic Details
Published in:Materials Science & Engineering C 2021-05, Vol.124, p.112076-112076, Article 112076
Main Authors: Fardous, Jannatul, Omoso, Yuji, Joshi, Akshat, Yoshida, Kozue, Patwary, Md Kawchar Ahmed, Ono, Fumiyasu, Ijima, Hiroyuki
Format: Article
Language:English
Subjects:
Anticancer properties
Antitumor agents
Bioavailability
Castor oil
Chemotherapy
Cytotoxicity
Drug delivery
Drug Delivery Systems
Emulsions
Gel-in-water
Hepatocytes
Hydrophobic drug
Hydrophobicity
Materials science
Melanoma
Metabolism
Nanoemulsion
Nanoemulsions
Nanoparticles
Organogel
Paclitaxel
Particle Size
Polydispersity
Polyoxyethylene
Side effects
Stability
Surface-Active Agents
Water
Zeta potential
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Summary:The effective delivery of anti-cancer drugs with minimal side effects and better therapeutic efficacy has remained an active area of research for many decades. Organogels have gained attention in recent years as potential drug delivery systems due to their high bioavailability, no first-pass metabolism and rapid action. Considering this, in the current study an organogel based nanoemulsion was developed aiming to effectively deliver hydrophobic drugs via encapsulation within in situ gellable organogel droplets, termed as gel-in-water (G/W) nanoemulsion. G/W nanoemulsion was prepared using a combination of lipiodol and organogelator 12-hydroxystearic acid (12-HSA) as inner gel phase; dispersed in water by ultrasonication and stabilized with polyoxyethylene hydrogenated castor oil (HCO-60) as a surfactant. The prepared nanoemulsion showed high drug loading efficiency (≈97%) with a mean diameter of 206 nm. Lower polydispersity index (PdI) value (≈0.1) suggests monodispersed nature of G/W nanoemulsion in the continuous phase. G/W nanoemulsion was found stable over six months in terms of particle size, zeta potential and pH at different storage temperatures. There was no cytotoxic effect of prepared G/W nanoemulsion on primary hepatocytes in vitro. In contrast, paclitaxel-loaded G/W showed a significant decrease in melanoma cell growth (*p 
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2021.112076